1190090-00-6Relevant articles and documents
Discovery of a small molecule inhibitor through interference with the gp120-CD4 interaction
Williams, David H.,Adam, Fiona,Fenwick, David R.,Fok-Seang, Juin,Gardner, Iain,Hay, Duncan,Jaiessh, Rawal,Middleton, Donald S.,Mowbray, Charles E.,Parkinson, Tanya,Perros, Manos,Pickford, Christopher,Platts, Michelle,Randall, Amy,Siddle, Daniel,Stephenson, Peter T.,Tran, Thien-Duc,Vuong, Hannah
scheme or table, p. 5246 - 5249 (2010/03/24)
A series of piperazine derivatives were designed and synthesised as gp120-CD4 inhibitors. SAR studies led to the discovery of potent inhibitors in a cell based anti viral assay represented by compounds 9 and 28. The rat pharmacokinetic and antiviral profiles of selected compounds are also presented. Crown Copyright
