15789-03-4

Basic information

• Product Name: BenzaMide, 3-hydroxy-N,N-diMethyl-
• Synonyms: BenzaMide, 3-hydroxy-N,N-diMethyl-;3-[(DiMethylaMino)carbonyl]phenol
• CAS NO: 15789-03-4
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.18914
• Mol File: 15789-03-4.mol
• Article Data: 9

Chemical Properties

• Melting Point: 133 °C(Solv: 1,4-dioxane (123-91-1))
• Boiling Point: 344.0±25.0 °C(Predicted)
• Appearance: /
• Density: 1.153±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 9.36±0.10(Predicted)
• CAS DataBase Reference: BenzaMide, 3-hydroxy-N,N-diMethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: BenzaMide, 3-hydroxy-N,N-diMethyl-(15789-03-4)
• EPA Substance Registry System: BenzaMide, 3-hydroxy-N,N-diMethyl-(15789-03-4)

Safety Data

• Hazardous Substances Data: 15789-03-4(Hazardous Substances Data)

Usage

Description

BenzaMide, 3-hydroxy-N,N-diMethylis an organic compound with the molecular formula C9H11NO2. It is a derivative of benzamide, featuring a hydroxyl group and two methyl groups attached to the nitrogen atom. BenzaMide, 3-hydroxy-N,N-diMethylis known for its potential applications in various fields due to its unique chemical structure and properties.

Uses

1. Pharmaceutical Industry:
BenzaMide, 3-hydroxy-N,N-diMethylis used as a synthetic intermediate for the development of novel purine and bicyclic pyrimidine compounds. These compounds act as factor Xa inhibitors, which are crucial in the treatment of various thrombotic disorders. The compound's high selectivity over thrombin and trypsin makes it a valuable asset in the design of targeted therapeutic agents.
2. Chemical Synthesis:
In the field of chemical synthesis, BenzaMide, 3-hydroxy-N,N-diMethylcan be utilized as a building block for creating a wide range of complex organic molecules. Its unique structure allows for further functionalization and modification, making it a versatile component in the synthesis of various pharmaceuticals, agrochemicals, and other specialty chemicals.
3. Research and Development:
BenzaMide, 3-hydroxy-N,N-diMethylis also used in research and development laboratories for studying the structure-activity relationships of various biologically active molecules. Its unique chemical properties make it an ideal candidate for probing the interactions between different molecular targets and potential drug candidates.

Upstream product

• 99-06-9 3-Carboxyphenol 
• 124-40-3 dimethyl amine 
• 16446-73-4 3-(chlorocarbonyl)phenyl acetate 
• 1391926-53-6 C₁₁H₁₃NO₃ 
• 7290-99-5 N,N-dimethyl-m-methoxybenzamide 
• 586-38-9 3-Methoxybenzoic acid 
• 68-12-2 N,N-dimethyl-formamide 
• 6304-89-8 3-acetoxybenzoic acid 

Downstream Products

• 81245-40-1 N,N-dimethyl-3-(methoxymethoxy)benzamide 
• 1352571-22-2 3-(tert-butyldimethylsilyloxy)-N,N-dimethylbenzamide 
• 1352571-23-3 3-(tert-butyldimethylsilyloxy)-N,N-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide 
• 1352571-24-4 3-hydroxy-5-(4-(4-methoxybenzyloxy)-5-methylpyrimidin-2-yl)-N,N-dimethylbenzamide 
• 1352570-25-2 N,N-dimethyl-3-(5-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)benzamide 
• 1352571-65-3 C₂₉H₂₉N₃O₆S 
• 1190090-00-6 C₂₄H₂₉N₃O₄ 
• 183307-51-9 3-[(6-(2-amino-5-cyanophenoxy)-3,5-difluoro-4-methylpyridin-2-yl)oxy]-N,N-dimethylbenzamide 

Relevant articles and documents

METHODS OF MAKING HIGH ENANTIOSELECTIVE SECONDARY ALCOHOLS

A new process to synthesis of compound OBI-3424 R-form and S-form products is provided. The "R-form" compound OBI-3423 was first synthesized with 48% overall yield from compound OBI-3424-5 by installation of the labile phosphate motif at later stage. The stereo chemistry is established by 5 steps chemo-enzyme combination synthesis to afford 99% optical purity, After then, the "S-form" compound OBI-3424 is prepared with improving overall yield of 54% from compound OBI-3424-5. The stereo chemistry is established by 4 steps combination of chemo-enzyme synthesis with excellent optical purity of 99%.

Camptothecin derivative with antitumor activity, and preparation method and application thereof

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(R)- AND (S)-1-(3-(3-N,N-DIMETHYLAMINOCARBONYL)PHENOXYL-4-NITROPHENYL)-1-ETHYL-N,N'-BIS (ETHYLENE)PHOSPHORAMIDATE, COMPOSITIONS AND METHODS FOR THEIR USE AND PREPARATION

Provided herein are optically active compounds of the formulae (ii); and (III) and pharmaceutical compositions thereof. Also provided herein are processes of making these compounds and resolving the racemic mixture or the enrichment of same with in one of