119024-29-2

Basic information

• Product Name: Acetic acid, (3,5-dichlorophenoxy)-, ethyl ester
• CAS NO: 119024-29-2
• Molecular Formula: C10H10Cl2O3
• Molecular Weight: 249.094
• Mol File: 119024-29-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Acetic acid, (3,5-dichlorophenoxy)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, (3,5-dichlorophenoxy)-, ethyl ester(119024-29-2)
• EPA Substance Registry System: Acetic acid, (3,5-dichlorophenoxy)-, ethyl ester(119024-29-2)

Safety Data

• Hazardous Substances Data: 119024-29-2(Hazardous Substances Data)

Upstream product

• 591-35-5 3,5-dichlorophenol 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 55502-54-0 3,5-dichlorophenoxyacetyl chloride 
• 1227692-21-8 2-(3,5-dichlorophenoxy)-N-methoxy-N-methylacetamide 
• 1227692-67-2 5-((3,5-dichlorophenoxy)methyl)-1H-pyrazol-3(2H)-one 
• 1226145-00-1 ethyl 4-(3,5-dichlorophenoxy)-3-oxobutanoate 

Relevant articles and documents

Expedient discovery for novel antifungal leads: 1,3,4-Oxadiazole derivatives bearing a quinazolin-4(3H)-one fragment

Developing novel fungicide candidates are intensively promoted by the rapid emergences of resistant fungi that outbreak on agricultural production. Aiming to discovery novel antifungal leads, a series of 1,3,4-oxadiazole derivatives bearing a quinazolin-4(3H)-one fragment were constructed for evaluating their inhibition effects against phytopathogenic fungi in vitro and in vivo. Systematically structural optimizations generated the bioactive molecule I32 that was identified as a promising inhibitor against Rhizoctonia solani with the in vivo preventative effect of 58.63% at 200 μg/mL. The observations that were captured by scanning electron microscopy and transmission electron microscopy demonstrated that the bioactive molecule I32 could induce the sprawling growth of hyphae, the local shrinkage and rupture on hyphal surfaces, the extreme swelling of vacuoles, the striking distortions on cell walls, and the reduction of mitochondria numbers. The above results provided an indispensable complement for the discovery of antifungal lead bearing a quinazolin-4(3H)-one and 1,3,4-oxadiazole fragment.

1,3,4-Thiadiazol-2-amine Derivatives as Urotensin-II Receptor (UT) Antagonists

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Synthesis and insect antifeedant activity of aurones against spodoptera litura larvae

A series of aurones were prepared from various phenols via phenoxy acetic acids and coumaranones and evaluated for insect antifeedant activity against the common cutworm (Spodoptera litura). The naturally occurring aurone was most active at an ED50 of 0.12 μmol/cm2. The synthetic precursor, coumaranones, showed that the introduction of methoxyl and methyl groups to the benzene ring increased insect antifeedant activity. Similarly, the tested aurones showed that the introduction of methoxyl group to the A and/or B rings increased the insect antifeedant activity, but 4,5,6- and 3 ,4 ,5 -trisubstituted compounds did not show this activity in this test. The hydroxylation of aurones in the B ring should be disadvantageous for insect antifeedant activity against S. litura. Although the melting points did not correlate well with the insect antifeedant activity, compounds that were nearly inactive had high melting points. A significant correlation was noted between biological activity (pED50) and a hydrogen-bonding parameter calculated from the Rf value obtained from SiOH thin-layer chromatography and a lipophilicity parameter (log k) calculated from the retention time in ODS high-performance liquid chromatography. The respective correlation coefficients (r) were -0.83 and -0.70. The introduction of alkoxy and alkyl groups along with adequate hydrogen bonding seems to contribute to the antifeedant activity of the compounds tested.