119056-15-4Relevant articles and documents
Vanilloid analogues containing resinferatoxin pharmacophores as potent vanilloid receptor agonists and analgesics, compositions and uses thereof
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, (2008/06/13)
The present invention is related to new vanilloid analogues containing resiniferatoxin pharmacophores, pharmaceutical compositions comprising such analogues, and their uses as vanilloid receptor agonists and potent analgesics. The present invention provides a pharmaceutical composition for treating acute, chronic, inflammatory or neuropathic pains or for treating bladder hypersensitivity.
Bicyclic beta-lactam carboxylic acids
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, (2008/06/13)
Compounds of the formula STR1 in which R1 is lower alkyl substituted by hydroxy or by protected hydroxy, R2 represents carboxy or functionally modified carboxy, R3 is hydrogen, amino, mono- or di-substituted amino, carbamoyl, hydroxy, protected hydroxy, carbamoyloxy, lower alkoxy, halogen, lower alkanoyl, sulphamoyl or heteroarylthio, each of R4 and R5, independently of the other, represents hydrogen, lower alkyl, hydroxy, protected hydroxy, lower alkoxy, halogen, amino, protected amino, lower alkanoylamino or carbamoyl, or R4 and R5 together represent methylenedioxy, Y represents a group of the formula --O--, --S-- or --NR6 --, R6 is hydrogen or lower alkyl, A1 represents lower alkylene or unsubstituted or substituted phenylene and A2 represents a direct bond or lower alkylene, and salts of such compounds, have antibacterial activity. The compounds of the formula I are manufactured by processes that are known per se.