1192024-61-5Relevant articles and documents
Asymmetric mannich-type reactions of fluorinated ketoesters with binaphthyl-modified thiourea catalysts
Kang, Young Ku,Yoon, Sung Je,Kim, Dae Young
experimental part, p. 1195 - 1200 (2011/11/06)
The catalytic enantioselective Mannich-type reaction promoted by chiral binaphthyl-modified bifunctional organocatalysts is described. The treatment of α-fluoro-β-ketoesters with N-Boc imines under mild reaction conditions afforded the corresponding β-aminated α-fluoro-β- ketoesters with excellent enantioselectivities (up to 98% ee).