119516-83-5 Usage
Description
1,4-Benzene-d4-diamine is an organic compound with the molecular formula C6H4(NH2)2-d4. It is a deuterated variant of 1,4-phenylenediamine, where some of the hydrogen atoms are replaced by deuterium, an isotope of hydrogen. 1,4-Benzene-d4-diamine is a brown solid and is commonly used in various applications due to its chemical properties.
Uses
1. Used in Hair Dye Industry:
1,4-Benzene-d4-diamine is used as a hair dye component for its ability to produce a range of colors when combined with other chemicals in the hair dye formulation. It serves as a contact allergen, which helps in the formation of the desired color upon oxidation.
2. Used in Pharmaceutical Industry:
1,4-Benzene-d4-diamine is used as a building block for the synthesis of various pharmaceutical compounds. Its chemical properties make it a versatile starting material for the development of new drugs with potential applications in the treatment of various diseases.
3. Used in Chemical Research:
Due to its unique deuterated structure, 1,4-Benzene-d4-diamine is used in chemical research as a stable isotope-labeled compound. This allows researchers to study the behavior of the molecule in various chemical reactions and processes, providing valuable insights into its properties and potential applications.
4. Used in Inflammatory Disease Treatment:
1,4-Benzene-d4-diamine, specifically as paraphenylenediamine, is used as a contact allergen for the treatment of inflammatory diseases. Its allergenic properties can help in modulating the immune response and provide relief from inflammation in certain conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 119516-83-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,9,5,1 and 6 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 119516-83:
(8*1)+(7*1)+(6*9)+(5*5)+(4*1)+(3*6)+(2*8)+(1*3)=135
135 % 10 = 5
So 119516-83-5 is a valid CAS Registry Number.
InChI:InChI=1/C6H8N2/c7-5-1-2-6(8)4-3-5/h1-4H,7-8H2/i1D,2D,3D,4D
119516-83-5Relevant articles and documents
Scalable and selective deuteration of (hetero)arenes
Bartling, Stephan,Beller, Matthias,Bourriquen, Florian,Brückner, Angelika,Junge, Kathrin,Kreyenschulte, Carsten,Lei, Aiwen,Li, Wu,Lund, Henrik,Rabeah, Jabor,Rockstroh, Nils,Surkus, Annette-Enrica,Yang, Dali
, (2022/01/19)
Isotope labelling, particularly deuteration, is an important tool for the development of new drugs, specifically for identification and quantification of metabolites. For this purpose, many efficient methodologies have been developed that allow for the small-scale synthesis of selectively deuterated compounds. Due to the development of deuterated compounds as active drug ingredients, there is a growing interest in scalable methods for deuteration. The development of methodologies for large-scale deuterium labelling in industrial settings requires technologies that are reliable, robust and scalable. Here we show that a nanostructured iron catalyst, prepared by combining cellulose with abundant iron salts, permits the selective deuteration of (hetero)arenes including anilines, phenols, indoles and other heterocycles, using inexpensive D2O under hydrogen pressure. This methodology represents an easily scalable deuteration (demonstrated by the synthesis of deuterium-containing products on the kilogram scale) and the air- and water-stable catalyst enables efficient labelling in a straightforward manner with high quality control. [Figure not available: see fulltext.].
