624-18-0

Basic information

• Product Name: p-Phenylenediamine dihydrochloride
• Synonyms: 1,4-PHENYLENEDIAMINE DIHYDROCHLORIDE;1,4-PHENYLENEDIAMMONIUM DICHLORIDE;1,4-DIAMINOBENZENE DIHYDROCHLORIDE;1,4-BENZENEDIAMINE DIHYDROCHLORIDE;4-PHENYLENEDIAMINE DIHYDROCHLORIDE;4-AMINOANILINE DIHYDROCHLORIDE;C.I. 76061;ρ-Phenylene diamine dihydrochlorie
• CAS NO: 624-18-0
• Molecular Formula: C₆H₁₀N₂*2Cl
• Molecular Weight: 181.06
• EINECS: 210-834-9
• Product Categories: Intermediates of Dyes and Pigments;Amine Salts;Building Blocks;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks
• Mol File: 624-18-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: >200°C
• Boiling Point: 267.4 °C at 760 mmHg
• Flash Point: 135.9 °C
• Appearance: White to purple-gray/Crystalline Powder
• Density: 1.15 g/cm3
• Vapor Pressure: 0.00817mmHg at 25°C
• Storage Temp.: Store below +30°C.
• Solubility: Methanol (Slightly), Water (Slightly)
• Water Solubility: >=10 g/100 mL at 21 ºC
• Stability: Stable. Incompatible with acids, strong oxidizing agents.
• Merck: 14,7285
• BRN: 3911749
• CAS DataBase Reference: p-Phenylenediamine dihydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: p-Phenylenediamine dihydrochloride(624-18-0)
• EPA Substance Registry System: p-Phenylenediamine dihydrochloride(624-18-0)

Safety Data

• Hazard Codes: T,N
• Statements: 23/24/25-36-43-50/53
• Safety Statements: 28-36/37-45-60-61-28A
• RIDADR: UN 1673 6.1/PG 3
• WGK Germany: 3
• RTECS: ST0350000
• F: 8-9
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 624-18-0(Hazardous Substances Data)

Usage

Chemical Description

P-phenylenediamine dihydrochloride is a chemical used in the production of hair dyes and other cosmetic products.

Uses

Different sources of media describe the Uses of 624-18-0 differently. You can refer to the following data:
1. Dihydrochloride salt of 1,4-Phenylenediamine (P319845). A hair dye component, paraphenylenediamine, as a contact allergen for treatment of inflammatory diseases.
2. P-Phenylenediamine Dihydrochloride can be used for coloring of keratinous materials using at least an self-?oxidizing dye or a blue, purple or green oxidative dye and at least one fluorescent dye.

General Description

White to slightly reddish crystals or gray powder.

Air & Water Reactions

Water soluble.

Reactivity Profile

Acidic organic/inorganic salts, such as p-Phenylenediamine dihydrochloride, are generally soluble in water. The resulting solutions contain moderate to high concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.

Fire Hazard

Flash point data for p-Phenylenediamine dihydrochloride are not available; however, p-Phenylenediamine dihydrochloride is probably combustible.

InChI:InChI=1/C6H8N2.2ClH/c7-5-1-2-6(8)4-3-5;;/h1-4H,7-8H2;2*1H

Upstream product

• 7647-01-0 hydrogenchloride 
• 35008-62-9 4-(N-acetylamino)phenyl isothiocyanate 
• 106-50-3 1,4-phenylenediamine 
• 100-25-4 para-dinitrobenzene 
• 100-01-6 4-nitro-aniline 

Downstream Products

• 6976-08-5 N,N'''-p-phenylene-di-guanidine 
• 92492-55-2 N,N'-Bis-<4-chlor-butan-sulfonyl-(1)>-p-phenylendiamin 
• 26055-65-2 1,4-bis(guanidino)benzene dihydrochloride 
• 215528-87-3 3-Amino-N-[4-(3-amino-propionylamino)-phenyl]-propionamide 
• 166815-04-9 (S)-4-Amino-4-(2-{4-[3-((S)-2-amino-4-benzyloxycarbonyl-butyrylamino)-propionylamino]-phenylcarbamoyl}-ethylcarbamoyl)-butyric acid benzyl ester 
• 166814-65-9 (S)-4-(2-{4-[3-((S)-4-Benzyloxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-propionylamino]-phenylcarbamoyl}-ethylcarbamoyl)-4-tert-butoxycarbonylamino-butyric acid benzyl ester 
• 166814-66-0 (S)-4-{2-[4-(3-{(S)-4-Benzyloxycarbonyl-2-[((S)-5-oxo-pyrrolidine-2-carbonyl)-amino]-butyrylamino}-propionylamino)-phenylcarbamoyl]-ethylcarbamoyl}-4-[((S)-5-oxo-pyrrolidine-2-carbonyl)-amino]-butyric acid benzyl ester 
• 166814-78-4 (S)-2-Amino-N-(2-{4-[3-((S)-2-amino-3-benzyloxy-propionylamino)-propionylamino]-phenylcarbamoyl}-ethyl)-3-benzyloxy-propionamide 
• 166814-54-6 [2-benzyloxy-1-(2-{4-[3-(3-benzyloxy-2-tert-butoxycarbonylamino-propionylamino)-propionylamino]-phenylcarbamoyl}-ethylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester 
• 166814-55-7 C₄₄H₄₆N₈O₈ 
• 166814-83-1 C₄₆H₅₀N₈O₈ 

Relevant articles and documents

Reduction of dinitrobenzenes by electron-carrying catalysts in the electrosynthesis of diaminobenzenes

The interaction of isomeric dinitrobenzenes (DNBs) with titanium(III), tin(II), and vanadium(II) chlorides, which are reducing agents used as electron carriers in the electrosynthesis of diaminobenzenes, has been studied. Rate constants of the reduction of isomeric DNBs and nitrophenylhydroxylamines by SnCl2 and TiCl3 in a 2 M water-alcohol solution (10 vol.% C2H5OH) of HCl were measured, and activation energies of the reduction of isomeric DNBs were determined. The rates of interaction of DNBs with the listed mediators increase in the series SnCl2 3 2. It is shown that the electrolysis of DNBs in the presence of an excess of these mediators makes it possible to obtain the corresponding diaminobenzenes with a yield of 60–90%.

A Modular Phosphorylated Glycoluril-Derived Molecular Tweezer for Potent Binding of Aliphatic Diamines

A molecular tweezer based on a glycoluril-derived framework bearing four phosphate groups was synthesized and shown to be capable of binding organic amines in aqueous solution. This work reports the Ka values for 30 complexes of this molecular tweezer and amine guests, determined by means of 1H NMR titrations. Both the hydrophobic cavity and the phosphate groups contribute to the binding. Bulkier molecules and molecules bearing negatively charged groups like carboxylates in amino acids bind less tightly due to a steric clash and coulombic repulsion. The narrow cavity and the strong ionic interactions of the phosphate groups with ammonium guests favor binding of aliphatic diamines. These binding properties clearly distinguish this system from structurally related molecular clips and tweezers.

FRICTIONLESS MOLECULAR ROTARY MOTORS

A rotaxane consisting of a cucurbituril and an uncharged guest molecule, having low or null affinity therebetween is provided as well as processes for providing the same. Various uses as energy converters (“frictionless” molecular motors), biochips and biosensors using the same are also provided.