1195769-01-7

Basic information

• Product Name: 4-[4-(3-amino-2-fluorophenyl)-2-(1,1-dimethylethyl)-1,3-thiazol-5-yl]-2-pyrimidinamine
• Synonyms: 4-[4-(3-amino-2-fluorophenyl)-2-(1,1-dimethylethyl)-1,3-thiazol-5-yl]-2-pyrimidinamine
• CAS NO: 1195769-01-7
• Molecular Weight: 343.428
• Mol File: 1195769-01-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-[4-(3-amino-2-fluorophenyl)-2-(1,1-dimethylethyl)-1,3-thiazol-5-yl]-2-pyrimidinamine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[4-(3-amino-2-fluorophenyl)-2-(1,1-dimethylethyl)-1,3-thiazol-5-yl]-2-pyrimidinamine(1195769-01-7)
• EPA Substance Registry System: 4-[4-(3-amino-2-fluorophenyl)-2-(1,1-dimethylethyl)-1,3-thiazol-5-yl]-2-pyrimidinamine(1195769-01-7)

Safety Data

• Hazardous Substances Data: 1195769-01-7(Hazardous Substances Data)

Upstream product

• 1195769-03-9 2-propen-1-yl {3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}carbamate 
• 161957-56-8 3-bromo-2-fluorobenzoic acid 
• 946126-94-9 2-fluoro-3-nitrobenzoic acid methyl ester 
• 206551-41-9 2-fluoro-3-bromobenzoic acid methyl ester 
• 630-22-8 2,2-dimethylpropanethioamide 
• 437-86-5 2-fluoro-3-nitrotoluene 
• 317-46-4 2-fluoro-3-nitro-benzoic acid 
• 1195768-18-3 3-amino-2-fluorobenzoic acid methyl ester 
• 1195768-27-4 (3-(2-(2-chloropyrimidin-4-yl)acetyl)-2-fluorophenyl)allylcarbamate 
• 1195768-26-3 methyl-3-[(allyloxy)carbonyl]amino-2-fluorobenzoate 
• 1195768-30-9 allyl(3-(2-tert-butyl-5-(2-chloropyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)carbamate 
• 1195768-31-0 3-[2-tert-butyl-5-(2-chloropyrimidin-4-yl)thiazol-4-yl]-2-fluoroaniline 
• 1195765-45-7 dabrafenib 

Downstream Products

• 1195767-60-2 N-{3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2-pyridinesulfonamide 
• 1307271-86-8 N-{3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2-propanesulfonamide 

Relevant articles and documents

Reductive Cleavage of Secondary Sulfonamides: Converting Terminal Functional Groups into Versatile Synthetic Handles

Sulfonamides are pervasive in pharmaceuticals and agrochemicals, yet they are typically considered as terminal functional groups rather than synthetic handles. To enable the general late-stage functionalization of secondary sulfonamides, we have developed a mild and general method to reductively cleave the N-S bonds of sulfonamides to generate sulfinates and amines, components which can further react in situ to access a variety of other medicinally relevant functional groups. The utility of this platform is highlighted by the selective manipulation of several complex bioactive molecules.