1199-00-4

Basic information

• Product Name: 3-METHYL-5-PHENYL-1,2,4-OXADIAZOLE
• Synonyms: 3-METHYL-5-PHENYL-1,2,4-OXADIAZOLE
• CAS NO: 1199-00-4
• Molecular Formula: C₉H₈N₂O
• Molecular Weight: 160.17
• Mol File: 1199-00-4.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 281.1°Cat760mmHg
• Flash Point: 126°C
• Appearance: /
• Density: 1.142g/cm³
• Vapor Pressure: 0.00618mmHg at 25°C
• Refractive Index: 1.542
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-METHYL-5-PHENYL-1,2,4-OXADIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYL-5-PHENYL-1,2,4-OXADIAZOLE(1199-00-4)
• EPA Substance Registry System: 3-METHYL-5-PHENYL-1,2,4-OXADIAZOLE(1199-00-4)

Safety Data

• Hazardous Substances Data: 1199-00-4(Hazardous Substances Data)

Usage

General Description

3-Methyl-5-phenyl-1,2,4-oxadiazole is a chemical compound with the molecular formula C9H8N2O. It is a heterocyclic compound containing both nitrogen and oxygen atoms in its five-membered ring structure. 3-METHYL-5-PHENYL-1,2,4-OXADIAZOLE is used in the synthesis of various pharmaceuticals, agrochemicals, and materials, and it exhibits potential biological activities such as anti-inflammatory, antioxidant, and antitumor properties. Additionally, it is also used as a building block in the production of organic electronic materials and as a fluorescence probe in biomedical applications. Overall, 3-Methyl-5-phenyl-1,2,4-oxadiazole is a versatile chemical with diverse applications in several industries.

InChI:InChI=1/C9H8N2O/c1-7-10-9(12-11-7)8-5-3-2-4-6-8/h2-6H,1H3

Upstream product

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Downstream Products

• 27350-74-9 5-butyl-3-methyl-5-phenyl-2⁽⁴⁾,5-dihydro-[1,2,4]oxadiazole 
• 110235-02-4 1,1,1-trifluoro-3-(5-phenyl-1,2,4-oxadiazol-3-yl)propane-2,2-diol 
• 87277-54-1 N-Benzoylacetimidsaeure-ethylester 
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• 948027-86-9 (Z)-N-[1-(2,2,3,3-tetramethylaziridin-1-yl)ethylidene]benzamide 
• 1575-95-7 N-acetylbenzamide 
• 55-21-0 benzamide 
• 93995-91-6 Bis-(1-benzamino-ethyl)-amin 
• 5692-19-3 N-benzoylacetamidine 

Relevant articles and documents

Beyond direct Nrf2 activation; reinvestigating 1,2,4-oxadiazole scaffold as a master key unlocking the antioxidant cellular machinery for cancer therapy

Harnessing the antioxidant cellular machinery has sparked considerable interest as an efficient anticancer strategy. Activating Nrf2, the master switch of the cellular redox system, suppresses ROS, alleviates oxidative stress, and halts cancer progression

A metal-free tandem approach to prepare structurally diverse N-heterocycles: Synthesis of 1,2,4-oxadiazoles and pyrimidinones

A metal-free one-pot approach to the diversity oriented synthesis of N-heterocycles, 1,2,4-oxadiazoles and 2,6 disubstituted pyrimidin-4-ones is described via carboxamidation of amidines with aryl carboxylic acids and aryl propargylic acids. The reactions occur at room temperature forming N-acylamidines which undergo tandem nucleophilic addition-deamination- intramolecular cyclisation to give the corresponding heterocyclic compounds in good to excellent yields. This one pot approach has led to the successful synthesis of the drug lead molecule, ataluren, 3-(5-(2-fluorophenyl)-1,2,4- oxadiazol-3-yl) benzoic acid in two steps. the Partner Organisations 2014.

Construction of 3,5-substituted 1,2,4-oxadiazole rings triggered by tetrabutylammonium hydroxide: A highly efficient and fluoride-free ring closure reaction of O-acylamidoximes

Tetrabutylammonium hydroxide (TBAH) is an efficient and mild alternative to tetrabutylammonium fluoride (TBAF) for base catalyzed cyclizations of 1,2,4-oxadiazoles from O-acylamidoximes. For most 3,5-substituted 1,2,4-oxadiazoles the reactions were dramatically accelerated by addition of 0.1 equiv of TBAH at room temperature. This method was also more generally applicable allowing for a wider range of substrates. Additionally, due to the absence of fluoride, TBAH will not result in corrosion of reactor vessels and therefore is better suited for large-scale synthesis.