120210-48-2 Usage
Description
TENIDAP, a nonsteroidal anti-inflammatory drug (NSAID), is primarily known for its preferential inhibition of COX-1 enzyme. It is effective in reducing inflammation and pain, making it a valuable pharmaceutical compound for various applications.
Uses
Used in Pharmaceutical Industry:
TENIDAP is used as an anti-inflammatory agent for the treatment of conditions such as osteoarthritis and rheumatoid arthritis. It helps in alleviating pain and inflammation by inhibiting the formation of pro-inflammatory arachidonic acid metabolites in human peripheral polymorphonuclear leukocytes.
Used in Inflammatory Conditions Treatment:
TENIDAP is used as a therapeutic agent for managing inflammation in various conditions. Its preferential inhibition of COX-1 makes it a suitable choice for reducing inflammation without causing significant side effects associated with other NSAIDs that inhibit both COX-1 and COX-2 enzymes.
Biological Activity
NSAID that preferentially inhibits COX-1 (IC 50 values are < 0.03, 1.2 and > 30 μ M for COX-1, COX-2 and 5-lipoxygenase respectively). Inhibits formation of pro-inflammatory arachidonic acid metabolites in isolated human peripheral polymorphonuclear leukocytes. Opener of inward rectifying hK IR 2.3 channel (EC 50 = 402 nM).
Check Digit Verification of cas no
The CAS Registry Mumber 120210-48-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,2,1 and 0 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 120210-48:
(8*1)+(7*2)+(6*0)+(5*2)+(4*1)+(3*0)+(2*4)+(1*8)=52
52 % 10 = 2
So 120210-48-2 is a valid CAS Registry Number.
InChI:InChI=1/C14H9ClN2O3S/c15-7-3-4-9-8(6-7)11(13(19)17(9)14(16)20)12(18)10-2-1-5-21-10/h1-6,19H,(H2,16,20)
120210-48-2Relevant articles and documents
New practical synthesis of tenidap
Porcs-Makkay, Marta,Simig, Gyula
, p. 10 - 16 (2000)
The development of a new, practical synthesis to tenidap is described. N,O-Dialkoxy(aryloxy)carbonylation of 5-chloro-2-oxo-2,3-dihydroindole, followed by removal of the O-alkoxy-(aryloxy)carbonyl group gave 1-[alkoxy(aryloxy)carbonyl]-5-chloro-2-oxo-2,3-dihydroindoles in good yields. The latter compounds were thenoylated in the 3-position. The role of DMAP in the acylation reaction is discussed. The structures of the thenoylated products and their enolate salts were investigated both in solution and solid phases. Ammonolysis of 5-chloro-3-[1-hydroxy-1-(2-thienyl)methylene]-2-oxo-1-phenoxycarbonyl-2,3- dihydroindole afforded the corresponding 1-carbamoyl derivative (tenidap) in high yield. The corresponding 1-ethoxy- and 1-methoxycarbonyl derivatives could not be similarly transformed to tenidap; loss of the alkoxycarbonyl moiety occurred instead of carbamoylation.
