120258-27-7

Basic information

• Product Name: 4-Bromo-2-ethylthiazole
• Synonyms: 4-Bromo-2-ethylthiazole
• CAS NO: 120258-27-7
• Molecular Formula: C₅H₆BrNS
• Molecular Weight: 192.07684
• Mol File: 120258-27-7.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-Bromo-2-ethylthiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-2-ethylthiazole(120258-27-7)
• EPA Substance Registry System: 4-Bromo-2-ethylthiazole(120258-27-7)

Safety Data

• Hazardous Substances Data: 120258-27-7(Hazardous Substances Data)

Usage

Uses

4-Bromo-2-ethylthiazole is involved in the preparation of epothilone E analogs via Stille coupling.

Upstream product

• 209260-74-2 2-vinyl-4-bromothiazole 

Downstream Products

• 15679-09-1 2-ethylthiazole 

Relevant articles and documents

Epothilone analogs

Epothilone A, epothilone B, analogs of epothilone and libraries of epothilone analogs are synthesized. Epothilone A and B are known anticancer agents that derive their anticancer activity by the prevention of mitosis through the induction and stabilization of microtubulin assembly. The analogs of epothilone are novel. Several of the anlogs are demonstrated to have a superior cytotoxic activities as compared to epothilone A or epothilone B as demonstrated by their enhanced ability to induce the polymerization and stabilization of microtubules.