209260-74-2

Basic information

• Product Name: 4-Bromo-2-vinylthiazole
• Synonyms: 4-Bromo-2-vinylthiazole
• CAS NO: 209260-74-2
• Molecular Formula: C5H4BrNS
• Molecular Weight: 190.063
• Mol File: 209260-74-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 252.9±32.0 °C(Predicted)
• Density: 1.663±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 4-Bromo-2-vinylthiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-2-vinylthiazole(209260-74-2)
• EPA Substance Registry System: 4-Bromo-2-vinylthiazole(209260-74-2)

Safety Data

• Hazardous Substances Data: 209260-74-2(Hazardous Substances Data)

Upstream product

• 7486-35-3 tri-n-butyl(vinyl)tin 
• 4175-77-3 2,4-dibromo-1,3-thiazole 

Downstream Products

• 15679-09-1 2-ethylthiazole 
• 120258-27-7 2-ethyl-4-bromothiazole 

Relevant articles and documents

Epothilone analogs

Epothilone A, epothilone B, analogs of epothilone and libraries of epothilone analogs are synthesized. Epothilone A and B are known anticancer agents that derive their anticancer activity by the prevention of mitosis through the induction and stabilization of microtubulin assembly. The analogs of epothilone are novel. Several of the anlogs are demonstrated to have a superior cytotoxic activities as compared to epothilone A or epothilone B as demonstrated by their enhanced ability to induce the polymerization and stabilization of microtubules.

Total synthesis of Epothilone E and related side-chain modified analogues via a stille coupling based strategy

A Stille coupling strategy has been utilized to complete a total synthesis of epothilone E from vinyl iodide 7 and thiazole-stannane 8h. The central core fragment 7 and its trans-isomer 11 were prepared from triene 15 using ring-closing metathesis (RCM),