1213099-69-4

Basic information

• Product Name: (S)-1-aMino-2,3-dihydro-1H-indene-4-carbonitrile-HCl
• Synonyms: (S)-1-aMino-2,3-dihydro-1H-indene-4-carbonitrile-HCl;(S)-1-Amino-2,3-dihydro-1H-indene-4-carbonitrile hydrochloride;(S)-1-AMINO-2,3-DIHYDRO-1H-INDENE-4-CARBONITRILE;(1S)-1-amino-2,3-dihydro-1H-indene-4-carbonitrile,hydrochloride
• CAS NO: 1213099-69-4
• Molecular Formula: C₁₀H₁₀N₂
• Molecular Weight: 194.66074
• Mol File: 1213099-69-4.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 297.7±40.0 °C(Predicted)
• Appearance: /
• Density: 1.17±0.1 g/cm3(Predicted)
• PKA: 8.72±0.20(Predicted)
• CAS DataBase Reference: (S)-1-aMino-2,3-dihydro-1H-indene-4-carbonitrile-HCl(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-aMino-2,3-dihydro-1H-indene-4-carbonitrile-HCl(1213099-69-4)
• EPA Substance Registry System: (S)-1-aMino-2,3-dihydro-1H-indene-4-carbonitrile-HCl(1213099-69-4)

Safety Data

• Hazardous Substances Data: 1213099-69-4(Hazardous Substances Data)

Usage

Description

(S)-1-aMino-2,3-dihydro-1H-indene-4-carbonitrile-HCl, also known as (S)-1-Amino-2,3-dihydro-1H-indene-4-carbonitrile Hydrochloride, is an organic compound with a unique molecular structure. It is characterized by its amine and carbonitrile functional groups, which contribute to its reactivity and potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
(S)-1-aMino-2,3-dihydro-1H-indene-4-carbonitrile-HCl is used as a reagent for the preparation of aryl(indanyl)oxadiazoles. These compounds serve as sphingosine 1 phosphate (S1P) receptor modulators, which are crucial in the treatment of S1P1-associated diseases. The ability of this compound to modulate S1P receptors makes it a valuable asset in the development of novel therapeutic strategies for a range of conditions.

Upstream product

• 1213591-14-0 (S)-1-amino-2,3-dihydro-1H-indene-4-carbonitrile di-p-toluoyl-L-tartaric acid 
• 60899-34-5 4-cyano-2,3-dihydro-1H-inden-1-one 
• 56461-20-2 1-oxoindane-4-carboxylic acid 
• 17640-21-0 isopropyl methoxyacetate 
• 34698-41-4 2,3-dihydro-1H-inden-1-amine 
• 776-79-4 2-(2-carboxyethyl)benzoic acid 
• 83-33-0 inden-1-one 
• 447-53-0 1,2-Dihydronaphthalene 
• 91-20-3 naphthalene 
• 612-17-9 1,4-dihydronaphthalene 
• 1213591-14-0 1-amino-2,3-dihydro-1H-indene-4-carbonitrile 
• 817-95-8 ethyl 2-ethoxyethanoate 
• 15115-60-3 4-bromo-2,3-dihydroinden-1-one 
• 1306763-24-5 (R)-1-hydroxy-2,3-dihydro-1H-indene-4-carbonitrile 

Downstream Products

• 1306760-86-0 5-(3-{(1S)-1-[(2-hydroxyethyl)amino]-2,3-dihydro-1H-inden-4-yl}-1,2,4-oxadiazol-5-yl)-2-[(propan-2-yl)oxy]benzonitrile 
• 1306763-31-4 tert-butyl N-[(1S)-4-cyano-2,3-dihydro-1H-inden-1-yl]carbamate 

Relevant articles and documents

Preparation method of ozanimod intermediate

The invention discloses a preparation method of an ozanimod intermediate, which comprises the following four steps: synthesis of 4-cyanoindene oxime, synthesis of N-(4-cyano-3H-indene-1-yl)-acetamide, synthesis of N-(4-cyanoindan-1-yl)-acetamide, and synthesis of (S)-1-amino-2, 3-dihydro-1H-indene-4-formonitrile. The method has the advantages of easily available and cheap raw materials, mild reaction conditions, free of dangerous intermediates and unstable intermediates, and high chiral selectivity.

PROCESS FOR THE PREPARATION OF SPHINGOSINE-1-PHOSPHATE RECEPTOR AGONIST

Industrially viable and advantageous processes for the preparation of Ozanimod are described. The invention also discloses the intermediates obtained in the process.

Preparation method of indane intermediate

The invention provides a preparation method of an indane intermediate, and belongs to the field of pharmaceutical chemicals. The method comprises the following steps: under the action of titanate, subjecting 2,3-dihydro-1-oxo-1H-indene-4-carbonitrile and