1215098-80-8

Basic information

• Product Name: diethyl 2-(5-bromopyridin-2-yl)malonate
• CAS NO: 1215098-80-8
• Molecular Weight: 316.151
• Mol File: 1215098-80-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: diethyl 2-(5-bromopyridin-2-yl)malonate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl 2-(5-bromopyridin-2-yl)malonate(1215098-80-8)
• EPA Substance Registry System: diethyl 2-(5-bromopyridin-2-yl)malonate(1215098-80-8)

Safety Data

• Hazardous Substances Data: 1215098-80-8(Hazardous Substances Data)

Upstream product

• 624-28-2 2,5-dibromopyridine 
• 105-53-3 diethyl malonate 
• 223463-13-6 2-iodo-5-bromopyridine 

Downstream Products

• 192642-85-6 2-(5-bromopyridin-2-yl)acetic acid 
• 1060814-88-1 ethyl 2-(5-bromopyridin-2-yl)acetate 
• 99986-02-4 ethyl 2-(5-ethylpyridin-2-yl)acetate 

Relevant articles and documents

TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS

A compound of formula I wherein: n is 1 or 2: p is 0 or 1; R1 is optionally one or more halo or methyl groups; R2a and R2b are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R2c and R2d are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R3a and R3b are independently selected from H and Me; R4 is either H or Me; R5 is either H or Me; R6a and R6b are independently selected from H and Me; A is either (i) optionally substituted phenyl; (ii) optionally substituted naphthyl; or (iii) optionally substituted C5-12 heteroaryl.

PYRROLO[2,3-D]PYRIMIDINE TROPOMYOSIN-RELATED KINASE INHIBITORS

The present invention relates to compounds of Formula (I) and their pharmaceutically acceptable salts, wherein the substituents are as described herein, and their use in medicine, in particular as Trk antagonists.