1220913-25-6

Basic information

• Product Name: (S)-3-benzyl-4-((3aR,7aS)-1H-isoindol-2(3H,3aH,4H,5H,6H,7H,7aH)-yl)-4-oxobutanoic acid
• Synonyms: (S)-3-benzyl-4-((3aR,7aS)-1H-isoindol-2(3H,3aH,4H,5H,6H,7H,7aH)-yl)-4-oxobutanoic acid
• CAS NO: 1220913-25-6
• Molecular Weight: 315.412
• Mol File: 1220913-25-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-3-benzyl-4-((3aR,7aS)-1H-isoindol-2(3H,3aH,4H,5H,6H,7H,7aH)-yl)-4-oxobutanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-benzyl-4-((3aR,7aS)-1H-isoindol-2(3H,3aH,4H,5H,6H,7H,7aH)-yl)-4-oxobutanoic acid(1220913-25-6)
• EPA Substance Registry System: (S)-3-benzyl-4-((3aR,7aS)-1H-isoindol-2(3H,3aH,4H,5H,6H,7H,7aH)-yl)-4-oxobutanoic acid(1220913-25-6)

Safety Data

• Hazardous Substances Data: 1220913-25-6(Hazardous Substances Data)

Upstream product

• 3972-36-9 (2S)-benzylsuccinic acid 
• 1470-99-1 cis-hexahydroisoindoline 
• 865538-96-1 (S)-3-benzyldihydrofuran-2,5-dione 

Downstream Products

• 145375-43-5 mitiglinide 

Relevant articles and documents

Novel mitiglinide calcium preparing method

The invention provides a novel mitiglinide calcium preparing method. According to the method, (S)-2-benzyl succinic acid is taken as the raw material, and deacidification is conducted to generate (S)-2-benzyl succinic anhydride; amidation is conducted between (S)-2-benzyl succinic anhydride and cis-hexahydroisoidolin to generate mitiglinide acid and an isomer byproduct; the isomer byproduct is separated out and subjected to isomerization to generate mitiglinide acid; acid-base salifying and salt exchange are conducted on the obtained mitiglinide acid to generate the product mitiglinide calcium. Compared with an existing anhydride-method technology, the method has the advantage that the purity of the product is improved remarkably. Compared with an active ester method and an amide method, the method has the advantages that the technology is simple, the yield is high, and production cost is low.