3972-36-9Relevant articles and documents
Asymmetric hydrogenation of itaconic acids with rhodium(I)-phenyl-CAPP complex; a correction
Jendralla
, p. 3671 - 3672 (1991)
Asymmetric hydrogenation of itaconic acids 2 under homogeneous catalysis of neutral Rh-complex 3 gives substituted succinic acids 4 of (S)-configuration with > 95% ee.
5-AMINO-4-CARBAMOYL-PYRAZOLE COMPOUNDS AS SELECTIVE AND IRREVERSIBLE T790M OVER WT-EGFR KINASE INHIBITORS AND USE THEREOF????
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Paragraph 0197, (2016/03/13)
Disclosed are compounds of Formula (I), pharmaceutical compositions comprising the same, processes for the preparation thereof, and the use thereof.
A practical and efficient preparation of (S)-2-benzylsuccinic acid: A key acid synthon of KAD-1229
Liu, Jian-Chao,Yang, Yu-She,Ji, Ru-Yun
, p. 2633 - 2640 (2007/10/03)
This report describes a practical and an efficient synthesis of (S)-2-benzyl-succinic acid, which was employed as a key intermediate for hypoglycemic KAD-1229 by means of asymmetric alkylation of N-acylsultam. The condensation of D-(-)-camphorsultam with 3-phenylpropionyl chloride gave N-acylsultam 1. N-acylsultam 1 reacted with 1.1 equimolar amount of sodium amide base to form chiral enolate, followed by alkylation with tert-butyl bromoacetate to afford 2. Cleavage of ester and saponification with H 2O2-LiOH provided the desired compound 5 with excellent yield and high optical purity.