1221157-03-4

Basic information

• Product Name: 2-ethoxy-5-(3,4,5-trimethoxyphenethyl)benzenamine
• Synonyms: 2-ethoxy-5-(3,4,5-trimethoxyphenethyl)benzenamine
• CAS NO: 1221157-03-4
• Molecular Weight: 331.412
• Mol File: 1221157-03-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-ethoxy-5-(3,4,5-trimethoxyphenethyl)benzenamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ethoxy-5-(3,4,5-trimethoxyphenethyl)benzenamine(1221157-03-4)
• EPA Substance Registry System: 2-ethoxy-5-(3,4,5-trimethoxyphenethyl)benzenamine(1221157-03-4)

Safety Data

• Hazardous Substances Data: 1221157-03-4(Hazardous Substances Data)

Upstream product

• 61240-20-8 triphenyl-(3,4,5-trimethoxybenzyl)phosphonium bromide 
• 1015697-68-3 (Z)-5-(4-ethoxy-3-nitrostyryl)-1,2,3-trimethoxybenzene 
• 1221157-02-3 3,4,5-trimethoxy-3'-nitro-4'-ethoxystilbene 
• 3011-34-5 4-hydroxy-3-nitrobenzaldehyde 
• 132390-61-5 4-ethoxy-3-nitrobenzaldehyde 

Downstream Products

• 1334740-34-9 3,4,5-trimethoxyphenyl-3'-amino-4'-ethoxydiphenylethane-Fmoc-glycineamide 
• 1221157-04-5 2-amino-N-(2-ethoxy-5-(3,4,5-trimethoxyphenethyl)phenyl)acetamide 

Relevant articles and documents

5-FLUOROURACIL DERIVATIVES, PREPARATION METHODS AND USES THEREOF

Disclosed is a 5-fluorouracil derivative having the molecular structure shown in general formula VI, in which Ra and Rb groups are an alkoxy group or a fluorine-substituted alkoxy group having 1, 2, 3, or 4 carbon atoms, and are mono-, bis-, tri-, tetra- or penta-substituted on a phenyl group; a linking group L1 is an alkyl or alkenyl group having 1, 2, 3, or 4 carbon atoms, a linking group L2 is oxygen, or an alkyl or alkoxy group having 1, 2, 3, or 4 carbon atoms, or an amino acid, or an alkyl group having 1, 2, 3, or 4 carbon atoms containing an amino moiety, or a furyl group, and an X group is O or —NH—. Further disclosed is a method for preparing such a derivative and a use of the same in the treatment of cancer, tumor diseases, and diseases caused by abnormal neovascularization in a human or non-human mammal, and a medicament or a composition containing the 5-fluorouracil derivative.

Combretastatin A-4 and Derivatives: Potential Fungicides Targeting Fungal Tubulin

Combretastatin A-4, first isolated from the African willow tree Combretum caffrum, is a tubulin polymerization inhibitor in medicine. It was first postulated as a potential fungicide targeting fungal tubulin for plant disease control in this study. Combretastatin A-4 and its derivatives were synthesized and tested against Rhizoctonia solani and Pyricularia oryzae. Several compounds have EC50 values similar to or better than that of isoprothiolane, which is widely used for rice disease control. Structure-activity relationship study indicated the the cis configuration and hydroxyl group in combretastatin A-4 are crucial to the antifungal effect. Molecular modeling indicated the binding sites of combretastatin A-4 and carbendazim on fungal tubulin are totally different. The bioactivity of combretastatin A-4 and its derivatives against carbendazim-resistant strains was demonstrated in this study. The results provide a new approach for fungicide discovery and fungicide resistance management.

ETHOXY DIPHENYL ETHANE DERIVATES, PREPARATION PROCESSES AND USES THEREOF

The invention discloses an ethoxydiphenylethane derivative and a synthetic method and uses thereof 4' position of phenylethane B aromatic ring is chemically modified by ethoxy and hydroxy at position 3' thereof is simultaneously modified to water soluble prodrug such as phosphate, and similarly, amino acid side chain is introduced to amino at position 3' to form amino acid amide water soluble prodrug having the structure shown as formula (I) the ethoxydiphenylethane derivative and the prodrug thereof include strong tubulin aggregation inhibiting ability and obvious target damage effect for tumor vessels, selectively cause dysfunction and structural damage of tumor vessels and induce apoptosis of vascular endothelial cells in order to play the role of killing tumor cells or inhibiting tumor metastasis in case that the tumor cells are free from the support of nutrition and oxygen.