1334740-34-9

Basic information

• Product Name: 3,4,5-trimethoxyphenyl-3'-amino-4'-ethoxydiphenylethane-Fmoc-glycineamide
• Synonyms: 3,4,5-trimethoxyphenyl-3'-amino-4'-ethoxydiphenylethane-Fmoc-glycineamide
• CAS NO: 1334740-34-9
• Molecular Weight: 610.707
• Mol File: 1334740-34-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3,4,5-trimethoxyphenyl-3'-amino-4'-ethoxydiphenylethane-Fmoc-glycineamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4,5-trimethoxyphenyl-3'-amino-4'-ethoxydiphenylethane-Fmoc-glycineamide(1334740-34-9)
• EPA Substance Registry System: 3,4,5-trimethoxyphenyl-3'-amino-4'-ethoxydiphenylethane-Fmoc-glycineamide(1334740-34-9)

Safety Data

• Hazardous Substances Data: 1334740-34-9(Hazardous Substances Data)

Upstream product

• 1015697-68-3 (Z)-5-(4-ethoxy-3-nitrostyryl)-1,2,3-trimethoxybenzene 
• 1221157-02-3 3,4,5-trimethoxy-3'-nitro-4'-ethoxystilbene 
• 3011-34-5 4-hydroxy-3-nitrobenzaldehyde 
• 132390-61-5 4-ethoxy-3-nitrobenzaldehyde 
• 29022-11-5 N-(fluoren-9-ylmethoxycarbonyl)glycine 
• 1221157-03-4 2-ethoxy-5-(3,4,5-trimethoxyphenethyl)benzenamine 

Downstream Products

• 1221157-04-5 2-amino-N-(2-ethoxy-5-(3,4,5-trimethoxyphenethyl)phenyl)acetamide 

Relevant articles and documents

Design, synthesis and anti-proliferative effects in tumor cells of new combretastatin A-4 analogs

Abstract A total of 11 novel combretastatin A-4 (CA-4) analogs were designed, synthesized, and evaluated for the anti-proliferative effects in tumor cells. The compounds represent four structural classes: (i) hydrogenated derivatives, (ii) ethoxyl derivatives, (iii) amino derivatives and (iv) pro-drugs. Biological evaluations demonstrate that multiple structural features control the biological potency. Three of the compounds, sit-1, sit-2 and sit-3, have potent anti-proliferative activity against multiple cancer cell lines. Their pro-drugs were synthesized to increase water solubility. Structure-activity relationship study and Surflex-Docking were studied in this paper. These results will be useful for the design of new CA-4 analogs that are structurally related to the SAR study.