1223405-87-5Relevant articles and documents
(2-Nitrophenyl)acetyl: A new, selectively removable hydroxyl protecting group
Daragics, Katalin,Fuegedi, Peter
supporting information; experimental part, p. 2076 - 2079 (2010/09/15)
Figure presented The utility of the (2-nitrophenyl)acetyl (NPAc) group for the protection of hydroxyl functions is reported. (2-Nitrophenyl)acetates are readily prepared starting from the commercially available, inexpensive (2-nitrophenyl)acetic acid, and these esters are stable under a series of common carbohydrate transformations. The NPAc group can be removed selectively using Zn and NH4Cl without affecting a series of common protecting groups. This new protecting group is orthogonal with the commonly used tert-butyldimethylsilyl, levulinoyl, 9-fluorenylmethoxycarbonyl, naphthylmethyl, and p-methoxybenzyl groups.