1224845-00-4

Basic information

• Product Name: Trans-2,3,6,7,12,12a-hexahydro-2-benzyl-6-phenyl-pyrazino[2',1';6,1]pyrido[3,4-b]indole-1,4-dione
• Synonyms: Trans-2,3,6,7,12,12a-hexahydro-2-benzyl-6-phenyl-pyrazino[2',1';6,1]pyrido[3,4-b]indole-1,4-dione
• CAS NO: 1224845-00-4
• Molecular Weight: 421.499
• Mol File: 1224845-00-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Trans-2,3,6,7,12,12a-hexahydro-2-benzyl-6-phenyl-pyrazino[2',1';6,1]pyrido[3,4-b]indole-1,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: Trans-2,3,6,7,12,12a-hexahydro-2-benzyl-6-phenyl-pyrazino[2',1';6,1]pyrido[3,4-b]indole-1,4-dione(1224845-00-4)
• EPA Substance Registry System: Trans-2,3,6,7,12,12a-hexahydro-2-benzyl-6-phenyl-pyrazino[2',1';6,1]pyrido[3,4-b]indole-1,4-dione(1224845-00-4)

Safety Data

• Hazardous Substances Data: 1224845-00-4(Hazardous Substances Data)

Upstream product

• 1447959-77-4 cis-ethyl 2-(2-chloroacetyl)-1-phenyl-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylate 
• 100-46-9 benzylamine 
• 100-52-7 benzaldehyde 
• 7479-05-2 L-tryptophan ethyl ester 
• 1227610-58-3 cis-1-phenyl-1,2,3,4-tetrahydro-9H-β-carboline-3-carboxylic acid ethyl ester 
• 50302-60-8 methyl 1-phenyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate 

Downstream Products

• 1224845-19-5 (6S,12aR)-2-benzyl-2,3,6,7,12,12a-hexahydro-6-phenyl-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione 

Relevant articles and documents

Synthesis of Functionalized Diketopiperazines as Cyclotryprostatin and Tryprostatin Analogues

Various ketopiperazines were synthesized as (cyclo)tryprostatin analogues. Construction of the skeleton started with a Pictet-Spengler reaction followed by acylation or alkylation of the piperidine nitrogen and condensation with a primary amine. 2-Chloroacetyl tetrahydro-β-carbolines rearranged towards the corresponding 2-chloro-N-[2-(1H-indol-3-yl)ethyl]acetamide deriv-atives upon treatment with NBS. These compounds were cyclized with primary amines towards the corresponding functionalized diketopiperazines. Georg Thieme Verlag Stuttgart . New York.