1227610-58-3Relevant articles and documents
Synthesis of Functionalized Diketopiperazines as Cyclotryprostatin and Tryprostatin Analogues
Nguyen Van, Tuyen,Claes, Pieter,De Kimpe, Norbert
supporting information, p. 1006 - 1010 (2013/06/27)
Various ketopiperazines were synthesized as (cyclo)tryprostatin analogues. Construction of the skeleton started with a Pictet-Spengler reaction followed by acylation or alkylation of the piperidine nitrogen and condensation with a primary amine. 2-Chloroacetyl tetrahydro-β-carbolines rearranged towards the corresponding 2-chloro-N-[2-(1H-indol-3-yl)ethyl]acetamide deriv-atives upon treatment with NBS. These compounds were cyclized with primary amines towards the corresponding functionalized diketopiperazines. Georg Thieme Verlag Stuttgart . New York.