122666-80-2

Basic information

• Product Name: (2S,3S)-8-Chloro-5-(2-dimethylamino-ethyl)-3-hydroxy-2-p-tolyl-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one
• Synonyms: (2S,3S)-8-Chloro-5-(2-dimethylamino-ethyl)-3-hydroxy-2-p-tolyl-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one
• CAS NO: 122666-80-2
• Molecular Weight: 390.934
• Mol File: 122666-80-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2S,3S)-8-Chloro-5-(2-dimethylamino-ethyl)-3-hydroxy-2-p-tolyl-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3S)-8-Chloro-5-(2-dimethylamino-ethyl)-3-hydroxy-2-p-tolyl-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one(122666-80-2)
• EPA Substance Registry System: (2S,3S)-8-Chloro-5-(2-dimethylamino-ethyl)-3-hydroxy-2-p-tolyl-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one(122666-80-2)

Safety Data

• Hazardous Substances Data: 122666-80-2(Hazardous Substances Data)

Upstream product

• 122666-77-7 (2S,3S)-3-(2-Amino-5-chloro-phenylsulfanyl)-2-hydroxy-3-p-tolyl-propionic acid methyl ester 
• 122666-78-8 3-(2-Amino-5-chloro-phenylsulfanyl)-2-hydroxy-3-p-tolyl-propionic acid 
• 100493-13-8 methyl 3-(p-tolyl)oxirane-2-carboxylate 
• 95-24-9 6-chloro-2-aminobenzothiazole 
• 23474-98-8 2-amino-5-chlorobenzenethiol 
• 145475-99-6 4-Chloro-2-(4-methyl-benzylsulfanyl)-phenylamine 
• 145476-01-3 N-[4-Chloro-2-(4-methyl-benzylsulfanyl)-phenyl]-N-(2-dimethylamino-ethyl)-oxalamic acid ethyl ester 
• 145476-00-2 N-[4-Chloro-2-(4-methyl-benzylsulfanyl)-phenyl]-oxalamic acid ethyl ester 
• 145475-98-5 4-Chloro-2-(4-methyl-benzylsulfanyl)-1-nitro-benzene 
• 104-82-5 4-Methylbenzyl chloride 
• 14371-79-0 2-nitro-5-chlorothiophenol 
• 145476-02-4 8-Chloro-5-(2-dimethylamino-ethyl)-2-p-tolyl-5H-benzo[b][1,4]thiazepine-3,4-dione 
• 4584-46-7 (2-chloroethyl)dimethylamine hydrochloride 
• 122666-79-9 (2S,3S)-8-Chloro-3-hydroxy-2-p-tolyl-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one 

Downstream Products

• 130884-57-0 4-Nitro-benzoic acid (2R,3R)-8-chloro-5-(2-dimethylamino-ethyl)-4-oxo-2-p-tolyl-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester 
• 130884-59-2 4-Chloro-2-nitro-benzoic acid (2R,3R)-8-chloro-5-(2-dimethylamino-ethyl)-4-oxo-2-p-tolyl-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester 
• 130884-55-8 Acetic acid (2R,3R)-8-chloro-5-(2-dimethylamino-ethyl)-4-oxo-2-p-tolyl-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester 

Relevant articles and documents

A new synthetic route to 1,5-benzothiazepines. Synthesis of derivatives of diltiazem

Several derivatives of diltiazem (9a-c) have been synthesized from the oxamate (6) through the carbon-carbon ring closure of the sulfur-stabilized benzylic anion and the ester carbonyl group, followed by stereoselective reduction of the C3-carb