1231764-55-8

Basic information

• Product Name: C₂₃H₃₃NO₂Si
• Synonyms: C₂₃H₃₃NO₂Si
• CAS NO: 1231764-55-8
• Molecular Weight: 383.606
• Mol File: 1231764-55-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₃H₃₃NO₂Si(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₃₃NO₂Si(1231764-55-8)
• EPA Substance Registry System: C₂₃H₃₃NO₂Si(1231764-55-8)

Safety Data

• Hazardous Substances Data: 1231764-55-8(Hazardous Substances Data)

Upstream product

• 176747-44-7 (2S,4R)-4-hydroxy-α,α-diphenyl-2-pyrrolidinemethanol 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Relevant articles and documents

Asymmetric Total Synthesis and Biological Evaluation of the Natural PDE4 Inhibitor Toddacoumalone

We describe herein the first asymmetric total synthesis and biological evaluation of the natural PDE4 inhibitor toddacoumalone and its stereoisomers. The key step of the total synthesis is a formal asymmetric [4 + 2] cycloaddition reaction catalyzed by chiral secondary amine catalysts. A variety of pyranoquinolinones and 3-methylcrotonaldehyde are well tolerated under the optimized reaction conditions, which paved the way for further SAR studies. Further biological evaluation showed 1a′ with the best PDE4 inhibitory activity (IC50 = 0.18 μM).