176747-44-7

Basic information

• Product Name: (2S,4R)-4-hydroxy-α,α-diphenyl-2-pyrrolidinemethanol
• Synonyms: (2S,4R)-4-hydroxy-α,α-diphenyl-2-pyrrolidinemethanol
• CAS NO: 176747-44-7
• Molecular Weight: 269.343
• Mol File: 176747-44-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (2S,4R)-4-hydroxy-α,α-diphenyl-2-pyrrolidinemethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4R)-4-hydroxy-α,α-diphenyl-2-pyrrolidinemethanol(176747-44-7)
• EPA Substance Registry System: (2S,4R)-4-hydroxy-α,α-diphenyl-2-pyrrolidinemethanol(176747-44-7)

Safety Data

• Hazardous Substances Data: 176747-44-7(Hazardous Substances Data)

Upstream product

• 1041199-38-5 (2S,4R)-ethyl 4-hydroxy-2-(hydroxydiphenylmethyl)pyrrolidine-1-carboxylate 
• 172947-80-7 (2S,4R)-1-ethyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate 
• 108-86-1 bromobenzene 
• 33996-30-4 trans-4-hydroxy-L-proline ethyl ester hydrochloride 
• 83487-17-6 (2S,4R)-(-)-N-methyloxycarbonyl-4-hydroxypyrrolidine-2-carboxylic acid methyl ester 
• 845965-30-2 (6R,7aS)-6-Hydroxy-1,1-diphenyl-tetrahydro-pyrrolo[1,2-c]oxazol-3-one 

Downstream Products

• 1173184-14-9 trans-4-hydroxy-α,α-diphenyl-L-prolinol hydrochloride 
• 1231764-55-8 C₂₃H₃₃NO₂Si 
• 1217168-94-9 ((2S,4R)-4-hydroxy-2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)(5-nitropyridin-2-yl)methanone 
• 1217168-93-8 ((2S,4R)-4-hydroxy-2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)(5-methoxypyridin-2-yl)methanone 
• 1217168-95-0 (6-bromopyridin-2-yl)((2S,4R)-4-hydroxy-2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)methanone 
• 1217168-96-1 ((2S,4R)-4-hydroxy-2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)(6-methylpyridin-2-yl)methanone 
• 1217168-92-7 ((2S,4R)-4-hydroxy-2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)(pyridin-2-yl)methanone 

Relevant articles and documents

H-bond-directing organocatalyst for enantioselective [4 + 2] cycloadditions via dienamine catalysis

An efficient, highly regio- and stereoselective [4 + 2] cycloaddition reaction to generate tetrahydropyranopyrazole frameworks has been developed. To this end, a dienamine-based catalytic strategy that relies on the H-bond-directing effect of the hydroxy group of a dinaphthylprolinol-type aminocatalyst has been used. This enables the synthesis of multifunctionalized heterocyclic derivatives with three contiguous stereocenters in good yields and excellent enantioselectivities.

NOVEL NI COMPLEX AND ITS DERIVATIVES, PRODUCING METHOD, AND THE USE THEREOF AS AN ANTIOXIDANT

The present invention relates to a novel nickel complex and its derivatives, which mimic the active site of Ni-containing superoxide dismutase (NiSOD). The five-coordinate Ni(II) and Ni(III) complexes or their derivatives, and six-coordinate derivatives have the following structures of formula (I) and (II): The nickel complexes and their derivatives of the invention act as anti-oxidants or free radical scavengers. The invented nickel complexes can be used in the preparation of medicines, health foods or cosmetics for human, animals and plants, or can be used in environmental or soil protection.

Chiral phosphinooxazolidine ligands for palladium- and platinum-catalyzed asymmetric Diels-Alder reactions

Cationic palladium (Pd)- and platinum (Pt)-phosphinooxazolidine catalysts 13a-c, 15a-d, 17a-c, and 19a-c were prepared from phosphinooxazolidine ligands 1-3, MCl2 (M = Pd and Pt), and counterions, and the activities of the catalysts in the asymmetric Diels-Alder (DA) reactions of cyclic or acyclic dienes with imide dienophiles were investigated. These catalysts demonstrated high levels of catalytic activity. The cationic Pd-POZ complex 13c provided particularly excellent enantioselectivity (98% ee) in the DA reactions of cyclopentadiene with acryloyl-, crotonyl-, and fumaroyl-1,3-oxazolidin-2-ones (20a-c).