1233937-25-1 Usage
Description
C31H33(2)H7O2, also known as Menaquinone-4-d7, is a labeled analogue of Menaquinone-4. Menaquinones are isoprenoid quinones of the naphthalene series and belong to the K2 Vitamin homologs. Menaquinone-4 is the most common type of vitamin K2 and is known as a hemostatic agent.
Uses
Used in Pharmaceutical Industry:
C31H33(2)H7O2 is used as a research tool for studying the metabolism and pharmacokinetics of Menaquinone-4. The labeled analogue allows for easier tracking and quantification of Menaquinone-4 in biological samples, providing valuable insights into its absorption, distribution, metabolism, and excretion.
Used in Clinical Research:
C31H33(2)H7O2 is used as a diagnostic aid in clinical research, helping to assess the vitamin K status of individuals and monitor the effectiveness of vitamin K supplementation or therapy.
Used in Osteoporosis Management:
C31H33(2)H7O2 is used as an adjunctive therapy for the pain of osteoporosis, as Menaquinone-4 has been shown to play a role in bone health and may help reduce pain associated with this condition.
Used in Hemostasis:
C31H33(2)H7O2 is used as a hemostatic agent, as Menaquinone-4 is known to be involved in blood clotting processes and can help prevent excessive bleeding.
Check Digit Verification of cas no
The CAS Registry Mumber 1233937-25-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,3,3,9,3 and 7 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1233937-25:
(9*1)+(8*2)+(7*3)+(6*3)+(5*9)+(4*3)+(3*7)+(2*2)+(1*5)=151
151 % 10 = 1
So 1233937-25-1 is a valid CAS Registry Number.
1233937-25-1Relevant articles and documents
Structure-activity relationships in the conversion of vitamin K analogues into menaquinone-4. Substrates essential to the synthesis of menaquinone-4 in cultured human cell lines
Suhara, Yoshitomo,Wada, Akimori,Tachibana, Yoji,Watanabe, Masato,Nakamura, Kanae,Nakagawa, Kimie,Okano, Toshio
, p. 3116 - 3124 (2010)
To reveal an essential biological role of menaquinone-4, we have clarified that dietary PK was converted to menaquinone-4 (MK-4) in animal tissues using deuterated vitamin K analogues. However, the kinds of analogue converted into MK-4 have not been elucidated. In this study, we examined structure-activity relationships in the conversion of several vitamin K analogues, with a substituted side chain, into MK-4 using cultured human cell lines. The results differed with the side chain of the analogues, that is, (1) the length of the isoprene unit and (2) the number of double bonds in the side chain. These findings would be useful for clarifying the mechanism of conversion of other vitamin K homologs into MK-4 as well as related enzymes.
