24034-73-9 Usage
Description
GERANYLGERANIOL, also known as a precursor to Geranylgeranylpyrophosphate (G367600), is an intermediate in the mevalonate pathway. It is characterized by its light yellow oil appearance and plays a significant role in various biological processes.
Uses
Used in Pharmaceutical Industry:
GERANYLGERANIOL is used as a therapeutic agent for preventing bone re-adsorption, inhibiting osteoclast formation, and kinase activation in vitro. Its role in the mevalonate pathway makes it a promising candidate for the development of treatments targeting bone-related conditions and diseases.
Used in Chemical Industry:
As a light yellow oil, GERANYLGERANIOL can be utilized as a raw material or intermediate in the synthesis of various chemical compounds and products, particularly those related to the pharmaceutical and healthcare sectors. Its unique chemical properties and position in the mevalonate pathway contribute to its versatility and applicability in this industry.
Biochem/physiol Actions
As the pyrophosphate, the metabolic precursor of all diterpenes. Screening in vitro shows this to be a potent and selective agent against Mycobacterium tuberculosis.
Check Digit Verification of cas no
The CAS Registry Mumber 24034-73-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,0,3 and 4 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 24034-73:
(7*2)+(6*4)+(5*0)+(4*3)+(3*4)+(2*7)+(1*3)=79
79 % 10 = 9
So 24034-73-9 is a valid CAS Registry Number.
InChI:InChI=1/C20H34O/c1-16(2)9-7-11-18(5)13-14-20(21)15-19(6)12-8-10-17(3)4/h9-10,13,15,20-21H,7-8,11-12,14H2,1-6H3/b18-13+,19-15+
24034-73-9Relevant articles and documents
Biosynthesis of sesterterpenes, head-to-tail triterpenes, and sesquarterpenes in Bacillus clausii: Identification of multifunctional enzymes and analysis of isoprenoid metabolites
Ueda, Daijiro,Yamaga, Hiroaki,Murakami, Mizuki,Totsuka, Yusuke,Shinada, Tetsuro,Sato, Tsutomu
, p. 1371 - 1377 (2015/06/16)
We performed functional analysis of recombinant enzymes and analysis of isoprenoid metabolites in Bacillus clausii to gain insights into the biosynthesis of rare terpenoid groups of sesterterpenes, head-to-tail triterpenes, and sesquarterpenes. We have identified an (all-E)-isoprenyl diphosphate synthase (E-IDS) homologue as a trifunctional geranylfarnesyl diphosphate (GFPP)/hexaprenyl diphosphate (HexPP)/heptaprenyl diphosphate (HepPP) synthase. In addition, we have redefined the function of a tetraprenyl-β-curcumene synthase homologue as that of a trifunctional sesterterpene/triterpene/sesquarterpene synthase. This study has revealed that GFPP, HexPP, and HepPP, intermediates of two isoprenoid pathways (acyclic terpenes and menaquinones), are biosynthesized by one trifunctional E-IDS. In addition, GFPP/HexPP and HepPP are the primary substrates for the biosynthesis of acyclic terpenes and menaquinone-7, respectively. Multifunctional terpene biosynthetic enzymes: Geranylfarnesyl diphosphate (GFPP), hexaprenyl diphosphate (HexPP), and heptaprenyl diphosphate (HepPP) are intermediates in two isoprenoid pathways and are biosynthesized by one trifunctional (all-E)-isoprenyl diphosphate synthase. GFPP/HexPP and HepPP are mainly utilized for the biosynthesis of acyclic terpenes and menaquinone-7, respectively.
