1236306-43-6

Basic information

• Product Name: N-(3-bromophenyl)-2-(4-(4-benzylphthalazin-1-yl)piperazin-1-yl)acetamide
• CAS NO: 1236306-43-6
• Molecular Weight: 516.44
• Mol File: 1236306-43-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(3-bromophenyl)-2-(4-(4-benzylphthalazin-1-yl)piperazin-1-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-bromophenyl)-2-(4-(4-benzylphthalazin-1-yl)piperazin-1-yl)acetamide(1236306-43-6)
• EPA Substance Registry System: N-(3-bromophenyl)-2-(4-(4-benzylphthalazin-1-yl)piperazin-1-yl)acetamide(1236306-43-6)

Safety Data

• Hazardous Substances Data: 1236306-43-6(Hazardous Substances Data)

Upstream product

• 2564-03-6 [(3-bromophenyl)-aminocarbonylmethyl]chloride 

Relevant articles and documents

Synthesis and antitumor activities of novel 1,4-disubstituted phthalazine derivatives

In an attempt to develop potent and selective antitumor agents,a series of novel 1,4-disubstituted phthalazine derivatives was designed and synthesized. All the prepared compounds were screened for their cytotoxic activities against A549,HT-29 and MDA-MB-231 cell lines in vitro. Among them,seven compounds (7a7e,7j and 7i) displayed excellent selectivity for MDA-MB-231 cells with IC50 values in the nM range,a desirable range for pharmacological testing. The most promising compound,7a (IC50 = 3.79 μ M,2.32 μ M,0.84 nM),was 5.6-,10.8-and 6.9 × 104-times more active than PTK-787 (IC50 = 21.16 μ M,22.11 μ M,57.72 μ M),respectively.