1239497-49-4Relevant articles and documents
Copper-Catalyzed C-H Difluoroalkylations and Perfluoroalkylations of Alkenes and (Hetero)arenes
Wang, Xiaoyang,Zhao, Shuang,Liu, Jing,Zhu, Dingsheng,Guo, Minjie,Tang, Xiangyang,Wang, Guangwei
, p. 4187 - 4190 (2017)
A general and facile synthetic method for C(sp2)-H difluoroalkylations and perfluoroalkylations of alkenes and (hetero)arenes with commercially available fluoroalkyl halides has been developed with a copper-amine catalyst system. This method is characterized by high yields, mild reaction conditions, low-cost catalyst, broad substrate scope, and excellent functional group compatibility, therefore providing a convenient synthetic strategy toward various difluoroalkyl- and perfluoroalkyl-substituted alkenes and (hetero)arenes.
Dual Fe/Pd-Catalyzed Reductive Cross-Coupling: Constructing gem-Difluoroallylenes with Alkenyl Bromides and Bromodifluoromethanes
Jiang, Yubo,Li, Tao,Luo, Yuhang,Qin, Guiping,Wu, Zefeng,Xiao, Tiebo
supporting information, p. 6700 - 6704 (2021/12/31)
Reported herein is an unprecedented dual iron/palladium-catalyzed reductive cross-coupling of alkenyl bromides and bromodifluoromethanes with manganese as the reductant. This methodology leads to the efficient construction of a series of gem-difluoroallylenes under mild reaction conditions without requiring the addition of stoichiometric amounts of catalyst. Preliminary mechanism investigations indicate that the radical pathway might not be involved in this novel dual transition metal catalyzed reaction.
