1241999-23-4Relevant articles and documents
Organocatalytic strategy for hydrophenolation of gem-difluoroalkenes
Orsi, Douglas L.,Yadav, M. Ramu,Altman, Ryan A.
, p. 4325 - 4336 (2019)
Gem-difluoroalkenes are an easily accessed fluorinated functional group, and a useful intermediate for elaborating into more complex fluorinated compounds. Currently, most functionalization reactions of gem-difluoroalkenes, with or without a transition metal-based catalyst system, involve the addition or removal of a fluorine atom to generate trifluorinated or monofluorinated products, respectively. In contrast, we present a complementary “fluorine-retentive” reaction that exploits an organocatalytic strategy to add phenols across gem-difluoroalkenes to deliver β,β-difluorophenethyl arylethers. The products are produced in good to moderate yields and selectivities, thus providing a range of compounds that are underrepresented in the synthetic and medicinal chemistry literature.
Cross coupling in water: Suzuki-Miyaura vinylation and difluorovinylation of arylboronic acids
Pschierer, Jan,Peschek, Natalie,Plenio, Herbert
experimental part, p. 636 - 642 (2010/08/20)
A general and efficient protocol for the Suzuki-Miyaura coupling of aryl boronic acids with vinylmesylate or difluorovinylmesylate or Cl 2CCF2 in water or water/n-butanol is reported, utilizing Na2PdCl4 (1 mol%) and a highly water-soluble fluorenylphosphine (CataCXium F sulf).
