87189-16-0

Basic information

• Product Name: POTASSIUM BROMODIFLUOROACETATE
• Synonyms: POTASSIUM BROMODIFLUOROACETATE;Potassium2-bromo-2,2-difluoroacetate;Potassium bromo(difluoro)acetate 97+%
• CAS NO: 87189-16-0
• Molecular Formula: C₂BrF₂O₂*K
• Molecular Weight: 213.02
• Mol File: 87189-16-0.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: POTASSIUM BROMODIFLUOROACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: POTASSIUM BROMODIFLUOROACETATE(87189-16-0)
• EPA Substance Registry System: POTASSIUM BROMODIFLUOROACETATE(87189-16-0)

Safety Data

• Hazardous Substances Data: 87189-16-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C2HBrF2O2.K/c3-2(4,5)1(6)7;/h(H,6,7);/q;+1/p-1

Upstream product

• 667-27-6 Ethyl bromodifluoroacetate 

Downstream Products

• 1241999-23-4 2-(2,2-difluorovinyl)-1,3-dimethylbenzene 
• 1501969-19-2 5-(2,2-difluorovinyl)-1,2,3-trimethoxybenzene 
• 1432484-45-1 (4-(2,2-difluorovinyl)phenyl)(methyl)sulfane 
• 1608-24-8 3-(2,2-difluoroethenyl)anisole 
• 38935-94-3 4-dimethylamino-β,β-difluorostyrene 
• 84750-94-7 1-(2,2-difluorovinyl)-3-nitrobenzene 
• 84750-93-6 1,1-difluoro-2-(4-bromophenyl)ethene 
• 90605-29-1 1-(2,2-difluorovinyl)-3-(trifluoromethyl)benzene 
• 10349-38-9 p-methoxyphenylisonitrile 
• 260352-79-2 2,2-difluorocyclopropanecarboxylic acid butyl ester 

Relevant articles and documents

Visible-Light-Promoted Synthesis of α-CF2H-Substituted Ketones by Radical Difluoromethylation of Enol Acetates

An efficient and novel visible-light-promoted radical difluoromethylation of enol acetates for the synthesis of α-CF2H-substituted ketones has been described. Upon irradiation under blue LED with catalytic amounts of fac-Ir(ppy)3, this photocatalytic procedure employs difluoromethyltriphenylphosphonium bromide as a radical precursor. Various α-CF2H-substituted ketones are successfully created via designed systems based on the SET process. The methodology has also provided an operationally simple process with broad functional group compatibility.

Nickel-Catalyzed Cross-Electrophile Coupling of the Difluoromethyl Group for Fluorinated Cyclopropane Synthesis

Herein, we report a new strategy for fluorinated cyclopropane synthesis. Photocatalytic olefin difluoromethylation is coupled with a nickel-catalyzed intramolecular cross-electrophile coupling (XEC) reaction between a difluoromethyl moiety and a benzylic ether. To the best of our knowledge, this is the first example of a XEC reaction employing a difluoromethyl group as an electrophile. A plausible mechanism is highlighted, and DFT calculations are included to support the observed stereochemical outcome.

FLUORINATION METHOD

The invention relates to a process for producing a compound comprising the anion [CF218FSO2]-, which process comprises treating a difluorocarbene source with (i) a source of 18F- and (ii) a source of SO2. The invention relates to a compound which comprises that anion. The invention also relates to the use of the compound comprising the anion [CF218FSO2]- to produce a compound comprising an 18F-trifluoromethyl functionalised aromatic group. Compounds comprising an 18F-trifluoromethyl functionalised aromatic group are also the subject of the present invention.