124409-98-9

Basic information

• Product Name: (R)-1-(6-amino-2,3-difluorophenoxy)propan-2-ol
• Synonyms: (R)-1-(6-amino-2,3-difluorophenoxy)propan-2-ol
• CAS NO: 124409-98-9
• Molecular Weight: 203.189
• Mol File: 124409-98-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-1-(6-amino-2,3-difluorophenoxy)propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-(6-amino-2,3-difluorophenoxy)propan-2-ol(124409-98-9)
• EPA Substance Registry System: (R)-1-(6-amino-2,3-difluorophenoxy)propan-2-ol(124409-98-9)

Safety Data

• Hazardous Substances Data: 124409-98-9(Hazardous Substances Data)

Upstream product

• 82419-26-9 2,3-difluoro-6-nitrophenol 
• 82419-32-7 3,4-difluoro-2-(2-oxopropyloxy)nitrobenzene 
• 124409-94-5 2,3-difluoro-6-nitro{[(R)-2-hydroxypropyl]oxy}benzene 
• 186750-51-6 (S)-1-(6-amino-2,3-difluorophenoxy)propan-2-ol 
• 124506-30-5 2,3-Difluoro-6-nitro-{[(S)-2-hydroxypropyl]oxy}benzene 
• 184686-18-8 (R) (-)-3,4-difluoro-2-(2-benzoyloxypropoxy)aniline 

Downstream Products

• 106939-42-8 (S)-7,8-difluoro-3,4-dihydro-3-methyl-2H-1,4-benzoxazine 

Relevant articles and documents

Chemoenzymatic Asymmetric Synthesis of 1,4-Benzoxazine Derivatives: Application in the Synthesis of a Levofloxacin Precursor

A versatile and general route has been developed for the asymmetric synthesis of a wide family of 3-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazines bearing different pattern substitutions in the aromatic ring. Whereas hydrolases were not suitable for resoluti

A facile synthesis of (S)-(-)-7,8-difluoro-3,4-dihydro-3-methyl-2H-1,4-benzoxazine by zinc chloride assisted Mitsunobu cyclization reaction

A convenient procedure for preparation of the title compound of ≤ 99% ee starting from 1-(2,3-difluoro-6-nitrophenoxy)-2-propanone (3) is presented. The key reaction is the intramolecular cyclization reaction in the presence of zinc chloride.