184686-18-8

Basic information

• Product Name: (R) (-)-3,4-difluoro-2-(2-benzoyloxypropoxy)aniline
• Synonyms: (R) (-)-3,4-difluoro-2-(2-benzoyloxypropoxy)aniline
• CAS NO: 184686-18-8
• Molecular Weight: 307.297
• Mol File: 184686-18-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R) (-)-3,4-difluoro-2-(2-benzoyloxypropoxy)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: (R) (-)-3,4-difluoro-2-(2-benzoyloxypropoxy)aniline(184686-18-8)
• EPA Substance Registry System: (R) (-)-3,4-difluoro-2-(2-benzoyloxypropoxy)aniline(184686-18-8)

Safety Data

• Hazardous Substances Data: 184686-18-8(Hazardous Substances Data)

Upstream product

• 124506-30-5 2,3-Difluoro-6-nitro-{[(S)-2-hydroxypropyl]oxy}benzene 
• 65-85-0 benzoic acid 
• 186750-51-6 (S)-1-(6-amino-2,3-difluorophenoxy)propan-2-ol 

Downstream Products

• 124409-98-9 (R)-1-(6-amino-2,3-difluorophenoxy)propan-2-ol 

Relevant articles and documents

A facile synthesis of (S)-(-)-7,8-difluoro-3,4-dihydro-3-methyl-2H-1,4-benzoxazine by zinc chloride assisted Mitsunobu cyclization reaction

A convenient procedure for preparation of the title compound of ≤ 99% ee starting from 1-(2,3-difluoro-6-nitrophenoxy)-2-propanone (3) is presented. The key reaction is the intramolecular cyclization reaction in the presence of zinc chloride.