1246551-25-6

Basic information

• Product Name: tert-butyl 3-oxohexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxylate
• Synonyms: tert-butyl 3-oxohexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxylate;tert-butyl 3-oxo-1,2,5,6,8,8a-hexahydroimidazo[5,1-c]pyrazine-7-carboxylate;tert-butyl-hexahydro-3-oxoimidazo[1,5-a]pyrazine-7(1H)-carboxylate
• CAS NO: 1246551-25-6
• Molecular Formula: C₁₁H₁₉N₃O₃
• Molecular Weight: 241.29
• Mol File: 1246551-25-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 212-213 °C
• Boiling Point: 426.6±44.0 °C(Predicted)
• Appearance: /
• Density: 1.23±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.25±0.20(Predicted)
• CAS DataBase Reference: tert-butyl 3-oxohexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 3-oxohexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxylate(1246551-25-6)
• EPA Substance Registry System: tert-butyl 3-oxohexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxylate(1246551-25-6)

Safety Data

• Hazardous Substances Data: 1246551-25-6(Hazardous Substances Data)

Usage

General Description

Tert-butyl 3-oxohexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxylate is a specific chemical compound with a complicated molecular structure. It is a carboxylate ester, containing a tert-butyl group, an oxo group, and a hexahydroimidazo[1,5-a]pyrazine ring. This chemical is commonly used in research and development, particularly in pharmaceutical and organic chemistry. Its precise properties and potential uses are still being explored, but it is likely to have diverse applications in various industries and academic fields.

Upstream product

• 129799-08-2 tert-butyl methyl piperazine-1,3-dicarboxylate 
• 143540-05-0 2-hydroxymethylpiperazine-1,4-dicarboxylic acid di-tert-butyl ester 
• 1256815-06-1 di-tert-butyl 2-((1,3-dioxoisoindolin-2-yl)methyl)-piperazine-1,4-dicarboxylate 
• 1256815-07-2 di-tert-butyl 2-(aminomethyl)piperazine-1,4-dicarboxylate 

Downstream Products

• 1002338-92-2 tert-butyl 2-(4-chlorophenyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazine-7(1H)-carboxylate 
• 1256816-01-9 tert-butyl 2-(4-cyanophenyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazine-7(1H)-carboxylate 
• 1256815-98-1 tert-butyl 2-(4-(trifluoromethyl)phenyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazine-7(1H)-carboxylate 
• 1002339-44-7 tert-butyl 2-(4-(methylsulfonyl)phenyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazine-7(1H)-carboxylate 
• 1256816-00-8 tert-butyl 2-(4-fluorophenyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazine-7(1H)-carboxylate 
• 1256815-93-6 C₁₉H₂₇N₃O₄ 
• 1256815-95-8 C₂₀H₂₉N₃O₅ 
• 1256815-96-9 tert-butyl 2-(3-cyanobenzyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazine-7(1H)-carboxylate 
• 1256815-94-7 C₁₉H₂₇N₃O₄ 
• 1256815-91-4 tert-butyl 2-(4-chlorobenzyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazine-7(1H)-carboxylate 
• 1256815-89-0 tert-butyl 2-(4-fluorobenzyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazine-7(1H)-carboxylate 
• 1256815-92-5 tert-butyl 2-(4-methoxybenzyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazine-7(1H)-carboxylate 
• 1256815-90-3 tert-butyl 2-(4-methylbenzyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazine-7(1H)-carboxylate 
• 1256815-88-9 tert-butyl 2-benzylhexahydro-3-oxoimidazo[1,5-a]pyrazine-7(1H)-carboxylate 

Relevant articles and documents

DIHYDROPYRIMIDINYLTHIAZOLE FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION

The present invention provides novel compounds having the general formula: wherein R1, R2, X, Y and A are as described herein, compositions including the compounds and methods of using the compounds.

Synthesis, biological assay in vitro and molecular docking studies of new imidazopyrazinone derivatives as potential dipeptidyl peptidase IV inhibitors

A series of novel imidazopyrazinone derivatives were synthesized and evaluated with regard to their ability to inhibit dipeptidyl peptidase IV (DPP-IV) in vitro. Of these compounds (2R)-4-oxo-4-[2-(3-carbamoylbenzyl)- hexahydro-3-oxoimidazo [1,5-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan- 2-amine fumaric acid (17h, IC50 = 78 nM) was shown to effectively inhibit the activity of the dipeptidyl peptidase IV enzyme. Molecular docking studies were also performed to illustrate the binding mode of compounds 15c and 17h. Favorable interactions were identified from the binding of inhibitor 15c with DPP-IV. By analogy to the binding mode of compound 15c, it seems that the introduction of a substituted benzyl moiety onto the imidazopyrazinone could remarkably improve the inhibitory activity of compound 17h.