125039-05-6Relevant articles and documents
Alkynylation of Thiolactams. New Synthesis of α-Substituted Pyrrolidine and Piperidine Alkaloids
Takahata, Hiroki,Takahashi, Koichi,Wang, Eng-Chi,Yamazaki, Takao
, p. 1211 - 1214 (2007/10/02)
Alkynylation of S-alkylthioamidium salts of thiolactams with lithium acetylides followed by reduction with LiAlH4 provided α-alkynylazacycloalkanes, which on reduction, or hydroboration followed by oxidation, gave α-substituted pyrrolidine and piperidine alkaloids.