1253056-05-1

Basic information

• Product Name: (S)-1-(2,4,5-trifluorophenyl)pent-4-en-2-amine
• Synonyms: (S)-1-(2,4,5-trifluorophenyl)pent-4-en-2-amine
• CAS NO: 1253056-05-1
• Molecular Weight: 215.218
• Mol File: 1253056-05-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-1-(2,4,5-trifluorophenyl)pent-4-en-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-(2,4,5-trifluorophenyl)pent-4-en-2-amine(1253056-05-1)
• EPA Substance Registry System: (S)-1-(2,4,5-trifluorophenyl)pent-4-en-2-amine(1253056-05-1)

Safety Data

• Hazardous Substances Data: 1253056-05-1(Hazardous Substances Data)

Upstream product

• 111991-20-9 2-(2,4,5-trifluorophenyl)acetaldehyde 
• 1253056-06-2 1-(2,4,5-trifluorophenyl)pent-4-en-2-amine 
• 220141-74-2 2-(2,4,5-trifluorophenyl)acetonitrile 
• 85116-38-7 (+)-diisopinocampheylallylborane 

Downstream Products

• 936630-57-8 (R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid 

Relevant articles and documents

Preparation method of Sitagliptin midbody of beta-amino acid

The invention discloses a preparation method of a Sitagliptin midbody of beta-amino acid. The method comprises the following steps of 2,4,5-fluorobenzene acetaldehyde 2, L-benzedrine alcohol and tributyl allyl tin alkanes perform asymmetrical allylation reaction under the effect of a catalyst A to obtain a compound 3; the compound 3 is oxidized to remove chiral auxiliary radials to obtain a compound 4; the compound 4 is subjected to amino radial protection to obtain a compound 5; the compound 5 is subjected to double-bond oxidation to obtain beta-aminobutyric acid 1. The method provided by the invention has the advantages that the raw materials are cheap and can be easily obtained; the reaction route is short; the operation is simple and convenient; the reaction conditions are mild; no special requirements exist on the equipment; the yield is high; the selectivity is high; good industrial application and economic values are realized.