936630-57-8Relevant articles and documents
Preparation method of 1,3-dicarbonyl compound and intermediate of the 1,3-dicarbonyl compound
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, (2020/05/02)
The invention discloses a preparation method of a 1,3-dicarbonyl compound and an intermediate of the 1,3-dicarbonyl compound, and particularly discloses a preparation method of a compound as shown ina formula I. The preparation method comprises the following step: in a solvent, performing an elimination reaction as shown in the specification on a compound as shown in a formula II to obtain the compound as shown in the formula I, wherein R is a tert-butoxy group, a methoxy group, an ethoxy group or a methyl group. The preparation method disclosed by the invention is relatively low in cost andbeneficial to industrial production.
A west geleg sandbank intermediate biological synthesis method (by machine translation)
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, (2019/07/04)
The invention discloses a west geleg sandbank intermediate biological synthesis method, namely in order to 4 - (2, 4, 5 - trifluoro methyl) uracil as the substrate under the action, by the one-pot preparation, Or, 4 - (2, 4, 5 - trifluoro methyl) uracil enzyme preparation obtained the situation that the (R)- 3 - carbamoyl amino - 4 - (2, 4, 5 - trifluorophenyl) butanoic acid, after separation, then the role of the enzyme or acid producing the (R)- 3 - amino - 4 - (2, 4, 5 - trifluorophenyl) butanoic acid, The west geleg sandbank intermediate the biological synthesis of simple process, without special request to device, to obtain a high EE value of the product, is suitable for industrial production. (by machine translation)
Glutamate as an Efficient Amine Donor for the Synthesis of Chiral β- and γ-Amino Acids Using Transaminase
Kim, Geon-Hee,Jeon, Hyunwoo,Khobragade, Taresh P.,Patil, Mahesh D.,Sung, Sihyong,Yoon, Sanghan,Won, Yumi,Sarak, Sharad,Yun, Hyungdon
, p. 1437 - 1440 (2019/02/06)
A recyclable glutamate amine donor system employing transaminase (TA), glutamate dehydrogenase (GluDH) and mutant formate dehydrogenase (FDHm) was developed, wherein amine donor Glu was regenerated using GluDH and thereby circumvented the inhibition of TA by α-ketoglutarate. Various enantiopure β-, γ-amino acids, and amines were successfully synthesized with high conversions and excellent enantiomeric excess using this system.