1253121-03-7Relevant articles and documents
Enantioselective synthesis of syn - And anti -1,3-aminoalcohols via β-aminoketones and subsequent reduction/dynamic kinetic asymmetric transformation
Millet, Renaud,Traeff, Annika M.,Petrus, Michiel L.,Baeckvall, Jan-E.
supporting information; experimental part, p. 15182 - 15184 (2011/01/05)
β-Aminoketones obtained from imines in an organocatalytic Mannich reaction were transformed to enantio- and diastereomerically pure 1,3-aminoalcohols with two stereogenic centers via a combined reduction/dynamic kinetic asymmetric transformation. Both syn and anti diastereomers were obtained in high yield, dr, and ee.