528586-23-4

Basic information

• Product Name: Carbamic acid, [(1S)-3-oxo-1-phenylbutyl]-, 1,1-dimethylethyl ester
• CAS NO: 528586-23-4
• Molecular Formula: C15H21NO3
• Molecular Weight: 263.337
• Mol File: 528586-23-4.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(1S)-3-oxo-1-phenylbutyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1S)-3-oxo-1-phenylbutyl]-, 1,1-dimethylethyl ester(528586-23-4)
• EPA Substance Registry System: Carbamic acid, [(1S)-3-oxo-1-phenylbutyl]-, 1,1-dimethylethyl ester(528586-23-4)

Safety Data

• Hazardous Substances Data: 528586-23-4(Hazardous Substances Data)

Upstream product

• 1088640-21-4 tert-butyl benzyloxy(3-oxo-1-phenylbutyl)carbamate 
• 167834-23-3 ethyl (3S)-3-{[(tert-butoxy)carbonyl]amino}-3-phenylpropanoate 
• 3082-69-7 ethyl (3S)-3-amino-3-phenylpropionate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 150884-50-7 benzaldehyde N-boc imine 
• 67-64-1 acetone 
• 458529-69-6 tert-butyl {(1S)-3-[methoxy(methyl)amino]-3-oxo-1-phenylpropyl}carbamate 
• 75-16-1 methylmagnesium bromide 
• 177896-09-2 tert-butyl benzylidenecarbamate 
• 1203706-68-6 (S)-methyl 2-((R)-(tert-butoxycarbonylamino)(phenyl)methyl)-3-oxobutanoate 

Downstream Products

• 1253121-03-7 (2R,4S)-4-(tert-butoxycarbonylamino)-4-phenylbutan-2-yl acetate 
• 1147347-30-5 (2S,4S)-4-(tert-butoxycarbonylamino)-4-phenylbutan-2-ol 
• 1147347-28-1 (2R,4S)-4-(tert-butoxycarbonylamino)-4-phenylbutan-2-ol 
• 1217068-89-7 Methyl 1-(1-{(3S)-3-[(tert-butoxycarbonyl)amino]-1-methyl-3-phenylpropyl}piperidin-4-yl)-2-methyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridine-5-carboxylate 
• 941704-85-4 methyl 3-(1-{(3S)-3-[(tert-butoxycarbonyl)amino]-1-methyl-3-phenylpropyl}piperidin-4-yl)-2-methyl-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridine-5-carboxylate 
• 941704-86-5 methyl 3-(1-{(3S)-3-[(tert-butoxycarbonyl)amino]-1-methyl-3-phenylpropyl}piperidin-4-yl)-2-methyl-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridine-5-carboxylate 
• 941706-40-7 (4S)-4-amino-4-phenylbutan-2-one 

Relevant articles and documents

Which is the actual catalyst: Chiral phosphoric acid or chiral calcium phosphate?

(Figure Presented) Both catalysts work: A highly enantioselective direct Mannich-type reaction of NBoc-protected aldimines with 1,3-dicarbonyl compounds has been developed with the use of a chiral phosphoric acid in the presence or absence of Ca . The absolute stereoselectivity of the phosphoric acid catalysis was found to be opposite to that of the calcium phosphate catalysis (see scheme; Boc = tert-butoxycarbonyl).

Effects of methyl substituents on the activity and enantioselectivity of homobenzotetramisole-based catalysts in the kinetic resolution of alcohols

Substitution of the tetrahydropyrimidine ring in the enantioselective acyl transfer catalyst homobenzotetramisole (HBTM) 6 with methyl groups exerts a dramatic influence on its performance in the kinetic resolution of secondary alcohols. The syn-3-methyl analogue of HBTM (9a) has proved to be superior to the parent compound in terms of catalytic activity, enantioselectivity, and synthetic accessibility.

Enantioselective mannich reactions with the practical proline mimetic N-(p-dodecylphenylsulfonyl)-2-pyrrolidinecarboxamide

A highly enantioselective and diastereoselective protocol for performing Mannich reactions has been developed by using a p-dodecylphenylsulfonamide-based proline catalyst. This catalyst facilitates the use of common, nonpolar solvents and increased concen