125520-01-6Relevant articles and documents
Synthesis of the tetrasaccharide glycoside moiety of Solaradixine and rapid NMR-based structure verification using the program CASPER
Angles d'Ortoli, Thibault,Widmalm, G?ran
, p. 912 - 927 (2016)
The major glycoalkaloid in the roots of Solanum laciniatum is Solaradixine having the branched tetrasaccharide β-d-Glcp-(1→2)-β-d-Glcp-(1→3)[α-l-Rhap-(1→2)]-β-d-Galp linked to O3 of the steroidal alkaloid Solasodine. We herein describe the synthesis of th
Synthesis of benzaldehyde-functionalized LewisX trisaccharide analogs for glyco-SAM formation
Kopitzki, Sebastian,Dilmaghani, Karim Akbari,Thiem, Joachim
, p. 10621 - 10636 (2013)
LewisX (Lex) antigen based carbohydrate-carbohydrate interactions are mediated by complexation of metal ions. Although theoretical studies about the influence of participating hydroxyl groups in the Le x trisaccharide head group (Gal
The synthesis and biological evaluation of mycobacterial p-hydroxybenzoic acid derivatives (p-HBADs)
Bourke, Jean,Brereton, Corinna F.,Gordon, Stephen V.,Lavelle, Ed C.,Scanlan, Eoin M.
, p. 1114 - 1123 (2014/02/14)
Mycobacterium tuberculosis establishes chronic infection and causes disease through manipulation of the host's innate and adaptive immune response. The bacterial cell wall is highly complex and contains a rich variety of glycosylated compounds that are se
CARBOHYDRATE FUNCTIONALISED SURFACES
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Paragraph 0200; 0206-0207, (2014/09/29)
Carbohydrates are biomolecules that are involved in a range of biological processes and play key roles in, for instance, host immune response and cellular adhesion. Accordingly, functionalisation of medical devices such as stents, valves, catheters, prostheses and other devices for in vivoimplantation with carbohydrates is an area in which considerable interest is developing. Disclosed herein are surfaces having carbohydrates immobilised thereon. The carbohydrate has a linker moiety covalently bound thereto and the linker moiety has a carbon atom that forms a covalent bond with an atom on the target surface. The carbon based bond is a strong, non-hydrolysable covalent bond. Diazonium salts are utilised to produce the functionalised surfaces and they are particularly advantageous as they result in non-toxic readily escapable by-products