125666-65-1

Basic information

• Product Name: 2,6-DIFORMYL-3,5-DIMETHOXYPHENOL
• Synonyms: 2,6-DIFORMYL-3,5-DIMETHOXYPHENOL;4-HYDROXY-2,6-DIMETHOXYISOPHTHALALDEHYDE;2,6-Diformyl-3,5-dimethoxyphenol 98%;2-Hydroxy-4,6-diMethoxyisophthalaldehyde;2,6-Diformyl-3,5-dimethoxyphenol, 4,6-Dimethoxy-2-hydroxybenzene-1,3-dicarboxaldehyde;4,6-Dimethoxy-2-hydroxyisophthalaldehyde 98%;4,6-Dimethoxy-2-hydroxyisophthalaldehyde98%;4,6-Dimethoxy-2-hydroxyisophthalaldehyde
• CAS NO: 125666-65-1
• Molecular Formula: C₁₀H₁₀O₅
• Molecular Weight: 210.18
• Product Categories: Aldehydes;blocks
• Mol File: 125666-65-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 214-218
• Boiling Point: 376.9 °C at 760 mmHg
• Flash Point: 150.8 °C
• Appearance: /
• Density: 1.32 g/cm³
• Vapor Pressure: 1.84E-07mmHg at 25°C
• Refractive Index: 1.607
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,6-DIFORMYL-3,5-DIMETHOXYPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-DIFORMYL-3,5-DIMETHOXYPHENOL(125666-65-1)
• EPA Substance Registry System: 2,6-DIFORMYL-3,5-DIMETHOXYPHENOL(125666-65-1)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 125666-65-1(Hazardous Substances Data)

Usage

General Description

2,6-DIFORMYL-3,5-DIMETHOXYPHENOL is a chemical compound commonly used in the field of organic chemistry. It is often used as a building block for the synthesis of various pharmaceuticals, polymers, and other organic compounds. 2,6-DIFORMYL-3,5-DIMETHOXYPHENOL is known for its aldehyde and methoxy functional groups, which make it valuable for its reactivity in organic reactions. Additionally, 2,6-DIFORMYL-3,5-DIMETHOXYPHENOL has demonstrated potential anti-inflammatory and antioxidant properties, which make it of interest in the field of medicinal chemistry. Overall, this compound has versatile applications and is a valuable tool for synthetic chemists and researchers.

InChI:InChI=1/C10H10O5/c1-14-9-3-8(13)6(4-11)10(15-2)7(9)5-12/h3-5,13H,1-2H3

Upstream product

• 500-99-2 3,5-dimethoxyphenol 
• 68-12-2 N,N-dimethyl-formamide 
• 7647-01-0 hydrogenchloride 
• 7446-70-0 aluminium trichloride 
• 708-76-9 2-hydroxy-4,6-dimethoxybenzaldehyde 
• 60-29-7 diethyl ether 

Downstream Products

• 859784-13-7 3,5-dimethoxy-2,6-dimethylphenol 

Relevant articles and documents

Preparation and application of the 5-(4-(9-fluorenylmethyloxycarbonyl) aminomethyl-3,5-dimethoxyphenoxy)-valeric acid (PAL) handle for the solid-phase synthesis of C-terminal peptide amides under mild conditions1-3

The acid-labile 5-(4-(9-fluorenylmethyloxycarbonyl) aminomethyl-3,5-dimethoxyphenoxy)valeric acid (PAL) handle 1 is described for the solid-phase synthesis of C-terminal peptide amides. The pure para isomer of 1 was prepared by each of two efficient five-step routes, in overall yields from 52% to 74%. The handle 1 was coupled onto a variety of amino group-containing supports to provide a general starting point for stepwise assembly of peptide chains according to a wide range of chemistries. In particular, protocols based on the base-labile N(α)-9-fluorenylmethyloxycarbonyl (Fmoc) group worked well with PAL handle 1. For small model peptides, final cleavage of tert-butyl side-chain protecting groups and of the anchoring linkage proceeded smoothly in trifluroacetic acid-dichloromethane-dimethyl sulfide (14:5:1) (reagent A) at 25 °C for 2 h. For cleavage of complex peptides that contain several sensitive side-chain functionalities, or that include arginine residues blocked with the 4-methoxy-2,3,6-trimethylphenylsulfonyl (Mtr) or 2,2,5,7,8-pentamethylchroman-6-ylsulfonyl (Pmc) groups, a mixture of trifluoroacetic acid-thioanisole-1,2-ethanedithiol-anisole (90:5:3:2) (reagent R), applied for 2-8 h at 25 °C, was preferred. A side reaction involving alkylation at tryptophan was elucidated, and conditions were developed to minimize its occurrence. The methodology was demonstrated by syntheses of over a hundred peptides, among which acyl carrier protein (65-74) amide (natural and retro sequences), luteinizing hormone-releasing hormone, adipokinetic hormone, PHI porcine fragment (18-27), and human gastrin-I are highlighted in this report. In comparative studies, the yields and purities of peptide amides prepared with PAL were shown to be equivalent or superior to those found for products prepared by alternative procedures from the recent literature.