1262305-02-1

Basic information

• Product Name: 2-(4-methoxyphenyl)-1,3-diazaspiro[4.4]nonan-4-one
• CAS NO: 1262305-02-1
• Molecular Weight: 246.309
• Mol File: 1262305-02-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-methoxyphenyl)-1,3-diazaspiro[4.4]nonan-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenyl)-1,3-diazaspiro[4.4]nonan-4-one(1262305-02-1)
• EPA Substance Registry System: 2-(4-methoxyphenyl)-1,3-diazaspiro[4.4]nonan-4-one(1262305-02-1)

Safety Data

• Hazardous Substances Data: 1262305-02-1(Hazardous Substances Data)

Upstream product

• 17193-28-1 1-aminocyclopentane-1-carboxamide 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 1262305-07-6 2-(4-methoxyphenyl)-1,3-diazaspiro[4.4]non-1-en-4-one 

Relevant articles and documents

Oxidation of substituted imidazolidin-4-ones: New alternative method preparation of 4,5-dihydro-1H-imidazol-5-ones

The reaction of aldehydes (pentanal, benzaldehyde, 4-methoxybenzaldehyde, 4-nitrobenzaldehyde, salicylaldehyde, pyridin-2-carbaldehyde) with 1-aminocyclopentancarboxamide or (S)-2-amino-2,3-dimethylbutanamide has been used to prepare substituted imidazolidin-4-ones 1a-g (a: R1 = CH 3(CH2)3; b: R1 = C6H 5; c: R1 = 4-CH3OC6H4; d: R1 = 4-NO2C6H4; e: R1 = 2-HOC6H4; f: R1 = 2-pyridyl; for R2 = R3 = (CH2)4), and g: R1 = 2-pyridyl; for R2 = CH3; R3 = CH(CH 3)2) in the yields of 53-83%. Subsequent oxidations with various reagents gave the corresponding 4,5-dihydro-1H-imidazol-5-ones 2a-g: Pd/C (72-93%), DDQ (25-80%), and MnO2 (30-77%). Structure of the prepared compounds 1a-g and 2a-g was verified by 1H NMR and 13C NMR spectroscopy, EI-MS and elemental analysis. X-ray diffraction was performed in the case of compounds 1e and 2e.