1262305-07-6

Basic information

• Product Name: 2-(4-methoxyphenyl)-1,3-diazaspiro[4.4]non-1-en-4-one
• Synonyms: 2-(4-methoxyphenyl)-1,3-diazaspiro[4.4]non-1-en-4-one
• CAS NO: 1262305-07-6
• Molecular Weight: 244.293
• Mol File: 1262305-07-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(4-methoxyphenyl)-1,3-diazaspiro[4.4]non-1-en-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenyl)-1,3-diazaspiro[4.4]non-1-en-4-one(1262305-07-6)
• EPA Substance Registry System: 2-(4-methoxyphenyl)-1,3-diazaspiro[4.4]non-1-en-4-one(1262305-07-6)

Safety Data

• Hazardous Substances Data: 1262305-07-6(Hazardous Substances Data)

Upstream product

• 1262305-02-1 2-(4-methoxyphenyl)-1,3-diazaspiro[4.4]nonan-4-one 
• 931-17-9 1,2-Cyclohexanediol 
• 51721-68-7 4-methoxybenzamidine hydrochloride 

Relevant articles and documents

OMS-2 nanorod-supported cobalt catalyst for aerobic dehydrocyclization of vicinal diols and amidines: Access to functionalized imidazolones

The development of reusable base metal catalysts for innovative catalytic transformations is a key technology toward sustainable production of fine chemicals, pharmaceuticals, and other function products. Herein, we report the preparation of a new highly dipersed manganese oxides of octahedral molecular sieve (OMS-2) nanorod-supported cobalt catalyst, which is successfully applied for aerobic dehydrocyclization of vicinal diols and amidines to access structurally diverse imidazolones, a class of valuable compounds found in numerous natural and biomedical products. The developed catalytic transformation proceeds with broad substrate scope, good functional group compability, the use of green molecular oxygen and reusable cobalt catalyst, which offers an important platform for the conversion of abundant and sustainable alcohol resources into functional N-heterocycles. The strategy combining nanocatalyst design with aerobic dehydrocoupling is anticipated to achieve other challenging catalytic transformations.

Oxidation of substituted imidazolidin-4-ones: New alternative method preparation of 4,5-dihydro-1H-imidazol-5-ones

The reaction of aldehydes (pentanal, benzaldehyde, 4-methoxybenzaldehyde, 4-nitrobenzaldehyde, salicylaldehyde, pyridin-2-carbaldehyde) with 1-aminocyclopentancarboxamide or (S)-2-amino-2,3-dimethylbutanamide has been used to prepare substituted imidazolidin-4-ones 1a-g (a: R1 = CH 3(CH2)3; b: R1 = C6H 5; c: R1 = 4-CH3OC6H4; d: R1 = 4-NO2C6H4; e: R1 = 2-HOC6H4; f: R1 = 2-pyridyl; for R2 = R3 = (CH2)4), and g: R1 = 2-pyridyl; for R2 = CH3; R3 = CH(CH 3)2) in the yields of 53-83%. Subsequent oxidations with various reagents gave the corresponding 4,5-dihydro-1H-imidazol-5-ones 2a-g: Pd/C (72-93%), DDQ (25-80%), and MnO2 (30-77%). Structure of the prepared compounds 1a-g and 2a-g was verified by 1H NMR and 13C NMR spectroscopy, EI-MS and elemental analysis. X-ray diffraction was performed in the case of compounds 1e and 2e.