126402-01-5Relevant articles and documents
Three-component (Domino) reaction affording substituted pyrroloquinazolines: Cyclization regioselectivity and stereoselectivity
Paleta, Oldrich,Dolensky, Bohumil,Palecek, Jiri,Kvicala, Jaroslav
, p. 1262 - 1270 (2013)
The cyclization involving 2-(aminomethyl)aniline, methyl 3,3,3-trifluoropyruvate, and various oxo compound afforded linearly annulated pyrroloquinazolines, for example, (2R,3aS)-2-hydroxy-3a-phenyl-2- trifluoromethyl-3,3a,4,9-tetrahydropyrrolo[2,1-b]quina
Novel and convenient aldolization of methyl 3,3,3-trifluoropyruvate using enamines instead of ketones
Palecek, Jiri,Paleta, Oldrich
, p. 521 - 524 (2004)
Piperidine enamines derived from acetone, acetophenone, cyclopentanone and cyclohexanone react easily in minutes with methyl 3,3,3-trifluoropyruvate (1) to afford products of the aldol condensation in high yields at room temperature, which is in contrast to the direct aldolization of 1 with the ketones.
Fluorinated butanolides and butenolides: Part 8. 2-(Trifluoromethyl)butan-4-olides by synthesis from methyl 3,3,3-trifluoropyruvate as building block
Paleta, Old?ich,Pale?ek, Ji?í,Dolensky, Bohumil
, p. 175 - 184 (2007/10/03)
2-Hydroxy-2-trifluoromethylbutan-4-olides (8-10) were prepared by a four step synthesis starting from a ketone and methyl 3,3,3-trifluoropyruvate (1) as a building block. Uncatalyzed chemospecific aldolization of ketones with 1 afforded 2 hydroxy-4-oxoest
