1266133-69-0Relevant articles and documents
Design, synthesis, and structure-activity relationships of indole-3-heterocycles as agonists of the CB1 receptor
Morrison, Angus J.,Adam, Julia M.,Baker, James A.,Campbell, Robert A.,Clark, John K.,Cottney, Jean E.,Deehan, Maureen,Easson, Anna-Marie,Fields, Ruth,Francis, Stuart,Jeremiah, Fiona,Keddie, Neil,Kiyoi, Takao,McArthur, Duncan R.,Meyer, Karsten,Ratcliffe, Paul D.,Schulz, Jurgen,Wishart, Grant,Yoshiizumi, Kazuya
scheme or table, p. 506 - 509 (2011/02/27)
Novel indole-3-heterocycles were designed and synthesized and found to be potent CB1 receptor agonists. Starting from a microsomally unstable lead 1, a bioisostere approach replacing a piperazine amide was undertaken. This was found to be a good strategy
