20656-61-5

Basic information

• Product Name: Methylmalonylchloride
• Synonyms: Methyl 2-Chloro 2-formyl acetate;Methylformyl chloroacetate;Methyl 2-chloro-3-oxopropanoate;2-Chloro-3-oxo-propionic acid methyl ester;Methyl 2-chloro-3-oxopropionate;Methyl chloromalonaldehydate;Propanoic acid, 2-chloro-3-oxo-, Methyl ester;Methyl 2-chloro-2-formylethanoate, Methyl 2-chloro-3-oxopropionate
• CAS NO: 20656-61-5
• Molecular Formula: C₄H₅ClO₃
• Molecular Weight: 136.5337
• Product Categories: Halogen compounds
• Mol File: 20656-61-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 156℃
• Flash Point: 64℃
• Appearance: /
• Density: 1.274
• PKA: 4.07±0.29(Predicted)
• CAS DataBase Reference: Methylmalonylchloride(CAS DataBase Reference)
• NIST Chemistry Reference: Methylmalonylchloride(20656-61-5)
• EPA Substance Registry System: Methylmalonylchloride(20656-61-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 20656-61-5(Hazardous Substances Data)

Usage

General Description

Methylmalonylchloride, also known as chloro(methyl)acetyl, is a chemical compound with the molecular formula C4H7ClO2. It is a colorless liquid with a pungent odor and is commonly used as a reagent in organic synthesis. Methylmalonylchloride is a versatile compound that can undergo various chemical reactions, including nucleophilic substitution and addition reactions. It is utilized in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. Additionally, it is also used in the preparation of compounds for use in the electronics industry. However, it is important to handle this compound with caution as it can be corrosive and harmful if inhaled, ingested, or if it comes into contact with skin. Therefore, proper safety measures and precautions should be taken when working with methylmalonylchloride.

Upstream product

• 107-31-3 Methyl formate 
• 96-34-4 methyl chloroacetate 
• 109-94-4 formic acid ethyl ester 

Downstream Products

• 14527-44-7 methyl thiazole-5-carboxylate 
• 6633-61-0 methyl 2-aminothiazole-5-carboxylate 
• 61367-57-5 2-(O⁵-benzoyl-β-D-ribofuranosyl)-thiazole-5-carboxylic acid methyl ester 
• 61367-53-1 2-(5-benzoyloxymethyl-furan-2-yl)-thiazole-5-carboxylic acid methyl ester 
• 1266133-69-0 C₂₁H₂₄N₂O₃S 
• 865712-82-9 2-(1-cyclohexylmethyl-7-methoxy-1H-indol-3-yl)-oxazole-5-carboxylic acid methyl ester 
• 53233-90-2 methyl 2-methylthiazole-5-carboxylate 
• 934470-16-3 methyl 2-[4-(benzyloxy)-3-cyanophenyl]-1,3-thiazole-5-carboxylate 
• 865712-83-0 1-cyclohexyl-methyl-7-methoxy-3-oxazol-2-yl-1H-indole 
• 124738-76-7 methyl 2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carboxylate 
• 133972-64-2 methyl 2-phenylaminothiazole-5-carboxylate 

Relevant articles and documents

Studies related to penicillins. I. 6-alpha-Chloropenicillanic acid and its reaction with nucleophiles.

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Preparation method of 5- flucytosine

The invention belongs to the technical field of chemical synthesis of medicines and relates to a preparation method of 5-flucytosine. The preparation method comprises the following steps: utilizing ethyl formate and methyl chloroformate to synthesize 2-chloro-3-oxo methyl propionate, then utilizing oxymethylisourea to close rings to obtain pyrimidine rings, utilizing potassium fluoride to substitute chlorine on the pyrimidine rings, utilizing phosphorus oxytrichloride to substitute hydroxyl groups on the pyrimidine rings, then adding ammonia water to lead chloride to be substituted with aminogroups, and hydrolyzing under an acid condition to obtain a product, namely the 5-flucytosine. The preparation method has the beneficial effects that the methyl chloroacetate is adopted for substituting methyl fluoroacetate to be used as a synthetic raw material of the 5-flucytosine, so that the use of highly-toxic chemicals such as the methyl fluoroacetate is avoided; simultaneously, since the price of the methyl chloroacetate is much lower than the price of the methyl fluoroacetate, the production cost can be saved; by utilization of the synthetic route provided by the invention, the higher-purity 5-flucytosine can be prepared without need of complex aftertreatment steps; simultaneously, the preparation method has higher overall yield and obvious industrial value and is worthy of being promoted and used on a large scale.

Inhibitors of histone deacetylase

Disclosed are compounds which inhibit histone deacetylase (HDAC) enzymatic activity. Also disclosed are pharmaceutical compositions comprising such compounds as well as methods to treat conditions, particularly proliferative conditions, mediated at least