1271994-34-3Relevant articles and documents
Enantioselective synthesis of axially chiral 1-arylisoquinolines by rhodium-catalyzed [2+2+2] cycloaddition
Sakiyama, Norifumi,Hojo, Daiki,Noguchi, Keiichi,Tanaka, Ken
, p. 1428 - 1432 (2011)
It's all in the application! An enantioselective synthesis of axially chiral 1-arylisoquinolines has been achieved, which involves a rhodium-catalyzed [2+2+2] cycloaddition of diphenylphosphinoyl-substituted 1-arylisoquinolines (see scheme). The new diphenylphosphinoyl-substituted axially chiral 1-arylisoquinolines were successfully derivatized to the corresponding axially chiral P,N ligand and Lewis base catalyst.
