1272317-42-6

Basic information

• Product Name: 1-(4-[2-fluorobenzyloxy]phenyl)-2-propen-1-one
• Synonyms: 1-(4-[2-fluorobenzyloxy]phenyl)-2-propen-1-one
• CAS NO: 1272317-42-6
• Molecular Weight: 256.276
• Mol File: 1272317-42-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(4-[2-fluorobenzyloxy]phenyl)-2-propen-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-[2-fluorobenzyloxy]phenyl)-2-propen-1-one(1272317-42-6)
• EPA Substance Registry System: 1-(4-[2-fluorobenzyloxy]phenyl)-2-propen-1-one(1272317-42-6)

Safety Data

• Hazardous Substances Data: 1272317-42-6(Hazardous Substances Data)

Upstream product

• 405-24-3 4-((2-fluorobenzyl)oxy)benzoic acid 
• 128982-48-9 methyl 4-(2-fluorobenzyloxy)benzoate 
• 1272317-41-5 4-(2-fluorobenzyloxy)-N-methyl-N-methoxybenzamide 
• 1826-67-1 vinyl magnesium bromide 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 446-48-0 o-fluorobenzyl bromide 

Downstream Products

• 934240-30-9 (2S,5R)-5-(4-((2-fIuorobenzyl)oxy)phenyl)pyrrolidine-2-carboxamide 
• 934240-31-0 (2S,5R)-5-(4-((2-fluorobenzyl)oxy)phenyl)pyrrolidine-2-carboxamide monohydrochloride 

Relevant articles and documents

PROCESS FOR PREPARING ALPHA-CARBOXAMIDE DERIVATIVES

The present application provides a process for the preparation of α-carboxamide pyrrolidine derivatives of formula (I), wherein R1 and R2 are independently hydrogen, C1-6alkyl or C3-6cycloalkylC1-6alkyl; or such R1 and R2, together with the nitrogen to which they are attached, may form an unsubstituted 3-, 4-, 5- or 6-membered saturated ring; X is carbon or nitrogen; n is 0, 1 or 2, wherein when present each R5 is independently selected from the list consisting of C1-3alkyl, halogen, cyano, haloC1-3alkyl, hydroxy, C1-3alkoxy and C1-3haloalkoxy; either R6 or R7 is -O-R8, -OCHR9R8, -NCH2R8 or -(CH2)2R8 wherein the other R6 or R7 is hydrogen or R5; and wherein R8 is a phenyl ring or wherein the phenyl ring is optionally substituted by one or more groups independently selected from the list consisting of C1-3alkyl, halogen, cyano, haloC1-3alkyl, hydroxy, C1-3alkoxy and C1-3haloalkoxy; and R9 is hydrogen or C1-3alkyl.