128982-48-9

Basic information

• Product Name: methyl 4-(2-fluorobenzyloxy)benzoate
• Synonyms: methyl 4-(2-fluorobenzyloxy)benzoate
• CAS NO: 128982-48-9
• Molecular Weight: 260.265
• Mol File: 128982-48-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methyl 4-(2-fluorobenzyloxy)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-(2-fluorobenzyloxy)benzoate(128982-48-9)
• EPA Substance Registry System: methyl 4-(2-fluorobenzyloxy)benzoate(128982-48-9)

Safety Data

• Hazardous Substances Data: 128982-48-9(Hazardous Substances Data)

Upstream product

• 446-48-0 o-fluorobenzyl bromide 
• 99-76-3 methyl 4-hydroxylbenzoate 

Downstream Products

• 934240-30-9 (2S,5R)-5-(4-((2-fIuorobenzyl)oxy)phenyl)pyrrolidine-2-carboxamide 
• 934240-31-0 (2S,5R)-5-(4-((2-fluorobenzyl)oxy)phenyl)pyrrolidine-2-carboxamide monohydrochloride 
• 1272317-41-5 4-(2-fluorobenzyloxy)-N-methyl-N-methoxybenzamide 
• 1272317-42-6 1-(4-[2-fluorobenzyloxy]phenyl)-2-propen-1-one 
• 405-24-3 4-((2-fluorobenzyl)oxy)benzoic acid 

Relevant articles and documents

Design and biological evaluation of phenyl imidazole analogs as hedgehog signaling pathway inhibitors

The hedgehog (Hh) signaling pathway is involved in diverse aspects of cellular events. Aberrant activation of Hh signaling pathway drives oncogenic transformation for a wide range of cancers, and it is therefore a promising target in cancer therapy. In the principle of association and ring-opening, we designed and synthesized a series of Hh signaling pathway inhibitors with phenyl imidazole scaffold, which were biologically evaluated in Gli-Luc reporter assay. Compound 25 was identified to possess high potency with nanomolar IC50, and moreover, it preserved the inhibition against wild-type and drug-resistant Smo-overexpressing cells. A molecular modeling study of compound 25 expounded its binding mode to Smo receptor, providing a basis for the further structural modification of phenyl imidazole analogs.

PROCESS FOR PREPARING ALPHA-CARBOXAMIDE DERIVATIVES

The present application provides a process for the preparation of α-carboxamide pyrrolidine derivatives of formula (I), wherein R1 and R2 are independently hydrogen, C1-6alkyl or C3-6cycloalkylC1-6alkyl; or such R1 and R2, together with the nitrogen to which they are attached, may form an unsubstituted 3-, 4-, 5- or 6-membered saturated ring; X is carbon or nitrogen; n is 0, 1 or 2, wherein when present each R5 is independently selected from the list consisting of C1-3alkyl, halogen, cyano, haloC1-3alkyl, hydroxy, C1-3alkoxy and C1-3haloalkoxy; either R6 or R7 is -O-R8, -OCHR9R8, -NCH2R8 or -(CH2)2R8 wherein the other R6 or R7 is hydrogen or R5; and wherein R8 is a phenyl ring or wherein the phenyl ring is optionally substituted by one or more groups independently selected from the list consisting of C1-3alkyl, halogen, cyano, haloC1-3alkyl, hydroxy, C1-3alkoxy and C1-3haloalkoxy; and R9 is hydrogen or C1-3alkyl.