127972-00-3

Basic information

• Product Name: 2-Methoxy-5-methylphenylboronic acid
• Synonyms: 5-Methyl-2-methoxyphenylboronic acid;(2-methoxy-5-methylphenyl)boronic acid(SALTDATA: FREE);2-Methoxy-5-Methylphenylboronic Acid (contains varying aMounts of Anhydride);2-Methoxy-5-methylphenylboronic acid >=95%;CHEMBRDG-BB 4008663;AKOS BRN-0586;5-METHOXY-2-METHYLPHENYL BORONIC ACID;2-METHOXY-5-METHYLPHENYLBORONIC ACID
• CAS NO: 127972-00-3
• Molecular Formula: C₈H₁₁BO₃
• Molecular Weight: 165.98
• Product Categories: Aryl;Organoborons;Boronic Acids;Boronic Acids and Derivatives;Boronic Acids;blocks;BoronicAcids;Substituted Boronic Acids;Heterocyclic Compounds;Alkoxy
• Mol File: 127972-00-3.mol
• Article Data: 11

Chemical Properties

• Melting Point: 92-97 °C(lit.)
• Boiling Point: 342.026 °C at 760 mmHg
• Flash Point: 160.652 °C
• Appearance: /
• Density: 1.14 g/cm³
• Vapor Pressure: 2.97E-05mmHg at 25°C
• Refractive Index: 1.52
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Soluble in methanol.
• PKA: 8.65±0.58(Predicted)
• CAS DataBase Reference: 2-Methoxy-5-methylphenylboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methoxy-5-methylphenylboronic acid(127972-00-3)
• EPA Substance Registry System: 2-Methoxy-5-methylphenylboronic acid(127972-00-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-60-37
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 127972-00-3(Hazardous Substances Data)

Usage

Chemical Properties

White solid

Uses

Different sources of media describe the Uses of 127972-00-3 differently. You can refer to the following data:
1. Reactant for:Coupling reactionsPreparation of selective quinazolinyl-phenol inhibitors of CHK1 as potential antitumors and radioprotectantsRh-catalyzed asymmetric arylation of aldehydesStereoselective hydroarylation reactionsSuzuki-Miyaura cross-coupling
2. suzuki reaction

InChI:InChI=1/C8H11BO3/c1-6-3-4-8(12-2)7(5-6)9(10)11/h3-5,10-11H,1-2H3

Upstream product

• 121-43-7 Trimethyl borate 
• 22002-45-5 2-bromo-4-methylanisole 
• 104-93-8 p-methylanizole 

Downstream Products

• 796975-81-0 9-(2-methoxy-5-methyl-phenyl)-anthracene 
• 1086462-70-5 C₁₈H₃₂N₆O₃ 
• 1086462-68-1 H-His(5-Br)-Leu-Leu-NH₂ 
• 1086462-72-7 C₂₆H₄₀N₆O₄ 
• 1152781-50-4 (E)-3-(2-methoxy-5-methylphenyl)-3-phenylacrylonitrile 
• 1196789-13-5 C₁₉H₁₈O₂ 
• 259209-21-7 (2-hydroxy-5-methylphenyl)boronic acid 
• 1269818-11-2 2-tert-butyl 1-ethyl 3-(2-methoxy-5-methylphenyl)-4,5,6,7-tetrahydro-2H-isoindole-1,2-dicarboxylate 
• 865350-37-4 2-(2-methoxy-5-methylphenyl)pyridine 
• 4373-61-9 2-(m-tolyl)pyridine 
• 859221-55-9 1-methoxy-4-methyl-2-(3,3,5,5-tetramethylcyclohex-1-enyl)benzene 

Relevant articles and documents

Evidence for Oxidative Decay of a Ru-Bound Ligand during Catalyzed Water Oxidation

In the evaluation of systems designed for catalytic water oxidation, ceric ammonium nitrate (CAN) is often used as a sacrificial electron acceptor. One of the sources of failure for such systems is oxidative decay of the catalyst in the presence of the st

New 5-aryl-1H-imidazoles display in vitro antitumor activity against apoptosis-resistant cancer models, including melanomas, through mitochondrial targeting

We designed and synthesized 48 aryl-1H-imidazole derivatives and investigated their in vitro growth inhibitory activity in cancer cell lines known to present various levels of resistance to proapoptotic stimuli. The IC50 in vitro growth inhibitory concentration of these compounds ranged from >100 μM to single digit μM. Among the most active compounds, 2i displayed similar in vitro growth inhibition in cancer cells independent of the cells' levels of resistance to proapoptotic stimuli and was found to be cytostatic in melanoma cell lines. Compound 2i was then tested by the National Cancer Institute Human Tumor Cell Line Anti-Cancer Drug Screen, and the NCI COMPARE algorithm did not reveal any correlation between its growth inhibition profiles with the NCI database compound profiles. The use of transcriptomically characterized melanoma models then enabled us to highlight mitochondrial targeting by 2i. This hypothesis was further confirmed by reactive oxygen production measurement and oxygen consumption analysis.

Block copolymers of highly isotactic polypropylene via controlled Ziegler-Natta polymerization

The block copolymerization polypropylene under highly isotactic stereocontrol, using a new catalyst obtained by means of rational ligand design, was discussed. Moderately isotactic polypropylenes of very low average molecular mass in reasonable yields was