128572-86-1

Basic information

• Product Name: (2S)-1-benzyloxy-3-chloro-propan-2-ol
• Synonyms: (2S)-1-benzyloxy-3-chloro-propan-2-ol
• CAS NO: 128572-86-1
• Molecular Weight: 200.665
• Mol File: 128572-86-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (2S)-1-benzyloxy-3-chloro-propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-1-benzyloxy-3-chloro-propan-2-ol(128572-86-1)
• EPA Substance Registry System: (2S)-1-benzyloxy-3-chloro-propan-2-ol(128572-86-1)

Safety Data

• Hazardous Substances Data: 128572-86-1(Hazardous Substances Data)

Upstream product

• 128572-85-0 2-acetoxy-1-(benzyloxy)-3-chloropropane 
• 56552-80-8 (R)-3-benzyloxy-1,2-propanediol 
• 51594-55-9 (R)-(-)-epichlorohydrin 
• 100-51-6 benzyl alcohol 
• 13991-52-1 1-chloro-2-hydroxy-3-phenylmethoxypropane 
• 2930-05-4 Benzyloxymethyl-oxiran 
• 151619-81-7 Butyric acid 2-benzyloxy-1-chloromethyl-ethyl ester 
• 67843-74-7 (S)-epichlorohydrin 

Relevant articles and documents

RAPAMYCIN ANALOGS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

METHOD OF PREPARATION OF OPTICALLY ACTIVE ALCOHOLS

The present invention relates to a method for preparing chiral alcohol having optical activity. More specifically, the present invention relates to a method for preparing (S)-chiral alcohol with a high yield and a high optical purity by mixing achiral substrates such as racemic alcohol or ketone with metal catalyst and protein hydrolase to perform a dynamic kinetic resolution reaction.

Enzymatic resolution of butanoic esters of 1-phenylmethyl and 1-[2-phenylethyl]ethers of 3-chloro-1,2-propanediol

The enzymatic hydrolysis of butanoic esters of 1-phenylmethyl- and 1-[2-phenylethyl] ethers of 3-chloro-1,2-propanediol has been studied by using lipases. Highest enantiomeric ratio was obtained with PPL for the phenylmethyl ether and with Amano SAM II for the phenylethyl ether. The absolute configurations of the products was verified in two ways. Both the produced alcohols and the remaining esters were converted into the corresponding glycidyl ethers which also were synthesised in homochiral forms starting from (S)-epichlorohydrin. The produced alcohols and the remaining esters were prepared independently from (S)-epichlorohydrin.